New enzyme could mean better drugs
Just as a choreographer's notation tells a dancer to strike a particular pose, an enzyme newly discovered by Rice University scientists is able to tell specific molecules precisely how to arrange themselves, down to the angle of single hydrogen bonds.....»»
Research identifies mechanism behind drug resistance in malaria parasite
Collaborating researchers have discovered a link between malaria parasites' ability to develop resistance to antimalarial drugs—specifically artemisinin (ART)—through a cellular process called transfer ribonucleic acid (tRNA) modification. tRNA m.....»»
Weight loss from Wegovy sustained for up to four years, trial shows
It's still unclear how long people will have to stay on the drugs to maintain the effects. Enlarge / Wegovy is an injectable prescription weight loss medicine that has helped people with obesity. (credit: Getty | Michael Siluk).....»»
An easy pill to swallow—new 3D printing research paves way for personalized medication
A new technique for 3D printing medication has enabled the printing of multiple drugs in a single tablet, paving the way for personalized pills that can deliver timed doses......»»
Scientists unlock key to breeding "carbon gobbling" plants with a major appetite
The discovery of how a critical enzyme "hidden in nature's blueprint" works sheds new light on how cells control key processes in carbon fixation, a process fundamental for life on Earth......»»
Researchers discover new function of oncoproteins
Researchers at the University of Würzburg have discovered a new function of the oncoprotein MYCN: It not only helps cancer cells to grow stronger, but also makes them more resistant to drugs. The study is published in Molecular Cell......»»
Dogma-challenging telomere findings may offer new insights for cancer treatments
A new study led by University of Pittsburgh and UPMC Hillman Cancer Center researchers shows that an enzyme called PARP1 is involved in repair of telomeres, the lengths of DNA that protect the tips of chromosomes, and that impairing this process can.....»»
Simulated chemistry: New AI platform designs tomorrow"s cancer drugs
Scientists at UC San Diego have developed a machine learning algorithm to simulate the time-consuming chemistry involved in the earliest phases of drug discovery, which could significantly streamline the process and open doors for never-before-seen t.....»»
Researchers: To tackle gendered violence, Australia also needs to look at drugs, trauma and mental health
After several highly publicized alleged murders of women in Australia, the Albanese government this week pledged more than A$925 million over five years to address men's violence towards women. This includes up to $5,000 to support those escaping vio.....»»
Nano-drugs hitching a ride on bacteria could help treat pancreatic cancer
Many pancreatic tumors are like malignant fortresses, surrounded by a dense matrix of collagen and other tissue that shields them from immune cells and immunotherapies that have been effective in treating other cancers. Employing bacteria to infiltra.....»»
Researchers decipher how an enzyme modifies the genetic material in the cell nucleus
Inside the cell nucleus, the DNA molecule is found in a densely packed DNA-protein complex known as chromatin. Here the DNA is wrapped around a core of histone proteins and densely packed to form nucleosomes. The structure of the nucleosomes determin.....»»
Team reports on relationship between contents of diosgenin and brassinosteroids in Dioscorea zingiberensis
Diosgenin, a secondary metabolite isolated from the Dioscorea spp. plant family, is an irreplaceable and ideal starting material for the synthesis of steroid hormone drugs. Dioscorea zingiberensis is the world's most desirable and important plant sou.....»»
Cows" milk particles used for effective oral delivery of drugs
Researchers have found that tiny particles present in cows' milk could offer, for the first time, an effective method for the oral delivery of RNA drugs......»»
Researchers unveil PI3K enzyme"s dual accelerator and brake mechanisms
A group of researchers have expanded conventional knowledge on a critical enzyme that controls cell migration. In a publication in the journal Nature Communications, they reported that phosphoinositide 3-kinase (PI3K) not only acts as an accelerator.....»»
European XFEL elicits secrets from an important nanogel
An international team at the world's largest X-ray laser European XFEL at Schenefeld near Hamburg has scrutinized the properties of an important nanogel that is often used in medicine to release drugs in a targeted and controlled manner at the desire.....»»
Probiotic feed additive, in place of antibiotics, found to boost growth and health in poultry
Antimicrobial resistance is an increasingly serious threat for public health, and the use of antimicrobials in livestock feed has been a major contributing factor in the emergence and spread of antimicrobial resistance to many drugs, according to the.....»»
"Miracle" weight-loss drugs could have reduced health disparities. Instead they got worse
"Miracle" weight-loss drugs could have reduced health disparities. Instead they got worse.....»»
Chemists devise easier new method for making a common type of building block for drugs
Ring-shaped chemical structures called saturated heterocycles are found in most FDA-approved drugs but are often difficult to create. Scripps Research chemists have just developed a surprisingly easy method for making many of these sought-after compo.....»»
US drug shortages reach record high with 323 meds now in short supply
The shortages affect everything from generic cancer drugs to ADHD medication. Enlarge / Takeda Pharmaceutical Co. Adderall XR brand medication arranged at a pharmacy in Provo, Utah, in November 2023. (credit: Getty | George Frey).....»»
MPA: Site-Blocking Will Stop Pirate Site Owners Who Abuse Kids & Traffick Drugs
After a wait of more than 12 years, rightsholders in the United States will again seek legislation that will provide the framework for a site-blocking regime to combat online piracy. After promoting and guiding similar regimes in dozens of countries.....»»
Scientists find new ways to convert inhibitors into degraders, paving the way for future drug discoveries
Researchers have discovered ways to convert inhibitor-style targeted cancer drugs into small molecules known as degraders, which help destroy cancer-promoting proteins in cells......»»