Molecular mechanism of ZDHHC18-mediated palmitoylation of cGAS in innate immunity inhibition
Cyclic GMP-AMP synthase (cGAS), a double-stranded DNA (dsDNA) sensing protein, plays an important role in the strong innate immune response induced by pathogen derived nucleic acids......»»
Genome sequence analysis identifies new driver of antimicrobial resistance
Antibiotics are a lifesaving tool. Yet, due to their chronic overuse, microbes are evolving and developing immunity against them. As a result, once-effective medications can no longer stave off infections, complicating treatment and increasing mortal.....»»
Researchers achieve aluminum molecular ring-based rotaxane and polyrotaxane
Rotaxanes have garnered interest for their unique structures consisting of mechanically interlocked axles and macrocycles. Numerous organic macrocycles have been employed to construct rotaxanes, including crown ether, cyclobis(paraquat-p-phenylene),.....»»
Researchers explore physiological and molecular processes underlying graft healing
Grafting has long been a cornerstone in agriculture and forestry, allowing for the propagation of desirable plant traits and improved resistance to environmental challenges. Despite its widespread application, grafting still encounters obstacles, inc.....»»
New mechanism uncovered for the reduction of emu wings
.Researchers have uncovered a novel mechanism underlying the skeletal reduction and asymmetry of emu wings. Their research reveals that the absence of distal muscle formation results in a lack of mechanostress during development, leading to the obser.....»»
Bioengineers create new substrate to study wood-decomposing enzyme
Researchers want to transform the natural and abundant resource wood into useful materials, and central to that is a molecular machine found in fungi that decomposes the complex raw material into its basic components......»»
DNA origami and fluorescent probes can precisely release molecular cargo
In the world of nanotechnology, the development of dynamic systems that respond to molecular signals is becoming increasingly important. The DNA origami technique, whereby DNA is programmed so as to produce functional nanostructures, plays a key role.....»»
Template synthesis creates multilayered perovskites with unique ferroelectric behavior
A group of Nagoya University researchers in Japan has synthesized 4- and 5-layered versions of the important electrical material perovskite. Analyzing the mechanism of ferroelectricity in the material, they found it has a unique function: the materia.....»»
Scientists find new epigenetic switch, revealing how genes are regulated in early development
The team of Professor Christof Niehrs at the Institute of Molecular Biology (IMB) in Mainz, Germany, has discovered that a DNA modification called 5-formylcytosine (5fC) functions as an activating epigenetic switch that kick-starts genes in early emb.....»»
Do bacteria age?
Any organism that lives, grows and reproduces must also age. People often think of aging in the physical sense—gray hair, slowed movements and wrinkles—but aging fundamentally occurs on a molecular level, inside of cells......»»
Scientists discover nonstomatal control of water loss in critical crops
Scientists have discovered that certain plants can survive stressful, dry conditions by controlling water loss through their leaves without relying on their usual mechanism—tiny pores known as stomata......»»
New strategy for simulating nonadiabatic dynamics of molecules at metal surfaces
A research team has proposed a novel approach to accurately describe electron transfer mediated nonadiabatic dynamics of molecules at metal surfaces. Their works were published in Physical Review Letters......»»
New technique boosts mutation rates in fruit flies for genetics research
A new technique, TF-High-Evolutionary (TF-HighEvo), allows large-scale assessment of de-novo mutations in multicellular organisms. Developed in collaboration with researchers from the European Molecular Biology Laboratory (EMBL) and the Friedrich Mie.....»»
Dual-feedback mechanism can enhance anti-oxidation coatings in fiber composites
Fiber-reinforced ceramic matrix composites (CMCs) have been the primary choice for radome materials in hypersonic vehicles due to their high toughness, strength, and other advantageous properties. However, oxidation by oxygen in the atmospheric envir.....»»
Researchers aim to control gene expression by studying the memories of cells
Communication between cells is now believed to activate a memory mechanism that sustains gene expression, a finding based on the work of Dr. Gregory Reeves......»»
Discovery about ice layer formation in ice sheets can improve sea level rise predictions
A newly discovered mechanism for the flow and freezing of ice sheet meltwater could improve estimates of sea level rise around the globe......»»
Catalyzing environmental cleanup: A highly active and selective molecular catalyst and electrified membrane
Some chemicals create environmental problems; others, fortunately, can help clean them up. Chemists from Yale University and their colleagues have developed an electrochemical catalyst and membrane that offers an efficient and sustainable way to trea.....»»
Human "molecular map" contributes to the understanding of disease mechanisms
Scientists at Weill Cornell Medicine in Qatar (WCM-Q) have created an intricate molecular map of the human body and its complex physiological processes based on the analysis of thousands of molecules in blood, urine and saliva samples from 391 volunt.....»»
Elucidating the mechanism underlying de novo membrane formation during gametogenesis
Researchers at University of Tsukuba have meticulously examined the gametogenesis of budding yeast, a process involving meiosis and spore formation, using live imaging techniques. Their findings reveal that during sporulation, the endoplasmic reticul.....»»
The olive tree"s blueprint: Key insights into high-quality oil production
A pivotal study has decoded the genetic basis of olive oil production, revealing a key regulatory mechanism that shapes oil biosynthesis. By mapping the olive tree's genome and metabolic pathways, researchers have identified how MYC2, a critical tran.....»»
New classical algorithm enhances understanding of quantum computing"s future
In an exciting development for quantum computing, researchers from the University of Chicago's Department of Computer Science, Pritzker School of Molecular Engineering, and Argonne National Laboratory have introduced a classical algorithm that simula.....»»