Molecular "hub" regulates gene-silencing proteins
To keep their vital functions in balance, many organisms use small snippets of RNA to "silence" messenger RNAs that code for certain proteins. New research from FMI scientists has revealed a molecular hub that integrates the activities of different p.....»»
With AI, extreme microbe reveals how life"s building blocks adapt to high pressure
An assist from a Google Artificial Intelligence tool has helped scientists discover how the proteins of a heat-loving microbe respond to the crushing conditions of the planet's deepest ocean trenches, offering new insights into how these building blo.....»»
Researchers examine protein arrangement in cell membrane that triggers programmed cell death
How can molecular structures be analyzed when the resolution of the techniques available is not sufficient? Researchers from the fields of physics, chemistry and medicine at Heinrich Heine University Düsseldorf (HHU) have combined and further develo.....»»
Scientists learn how to drug wily class of disease-causing enzymes
UCSF scientists have discovered how to target a class of molecular switches called GTPases that are involved in a myriad of diseases from Parkinson's to cancer and have long been thought to be "undruggable.".....»»
Glitch in protein synthesis could affect tumor growth
During protein synthesis, or translation, genetic information transcribed in the cell's mRNA directs the stringing together of amino acids—the building blocks of proteins. As the translation machinery carouses along the string of nucleotides that m.....»»
How context-specific factors control gene activity
Every cell in our body contains the same DNA, yet liver cells are different from brain cells, and skin cells differ from muscle cells. What determines these differences? It all comes down to gene regulation; essentially how and when genes are turned.....»»
Crystallized alternative DNA structure sheds light on insulin and diabetes
The first crystal structure of an alternative DNA shape from the insulin gene has been revealed by a UCL-led research team......»»
Q&A: How single-cell and spatial proteomics reveal proteins" nuanced roles in health and disease
When Steve Carr, senior director of the Proteomics Platform at the Broad Institute of MIT and Harvard, began working in proteomics, the field was able to detect only the most abundant proteins in a given sample. In recent years, increasingly sensitiv.....»»
Plant scientists link phospholipid sensing with control of gene expression
Plant scientists have long known that phosphorus is a crucial component in plant growth. A major discovery by a Kansas State University (K-State) biologist and her lab is leading to a better understanding of how plants detect and use that resource—.....»»
New mRNA and gene editing tools offer hope for dengue virus treatment
Dengue virus, a painful and sometimes fatal mosquito-borne infection well known in tropical countries, is surging rapidly across the planet. Now, 4 billion people live in places at risk for the disease, like the southeastern United States, which does.....»»
AI meets biophysics: New approach identifies critical interaction points in cancer-related proteins
Researchers at Auburn University, in collaboration with scientists from the University of Basel and ETH Zurich, have made an advance in the fight against cancer. The team, led by Dr. Rafael Bernardi, Associate Professor of Biophysics in the Departmen.....»»
Algorithm maps protein degradation patterns to improve infection diagnosis and treatment
Peptides are small fragments of proteins, mainly found in the skin and mucous membranes. Some peptides act as a barrier, protecting the body against infections by fighting off microorganisms like bacteria, viruses, and other pathogens, while others p.....»»
Researchers develop molecular biosensors that only light up upon binding to their targets
Biosensors—devices that use biological molecules to detect the presence of a target substance—have enormous potential for detecting disease biomarkers, molecules-in-action in diverse biological processes, or toxins and other harmful substances in.....»»
Regulatory gene influences shape recognition in medaka fish, scientists discover
Medaka fish that lack functional Hmgn2 genes are unable to distinguish between simple shapes, revealing a new function for the regulatory gene......»»
Labs collaborate to enhance imaging tools for cell observation
Two labs at the University of Utah's Department of Chemistry joined forces to improve imaging tools that may soon enable scientists to better observe signaling in functioning cells and other molecular-scale processes central to life......»»
RNA editing plays critical role in fruit flies" sense of smell and social interactions
Imagine your DNA as a set of instructions or a recipe book that tells your body how to make everything it needs to function, from proteins to cells. Every time the body needs to build something, it reads these instructions. But sometimes, the body ca.....»»
Scientists develop new TRV vector-based method for peach gene analysis
Peach, a valuable crop within the Rosaceae family, has historically faced challenges in genetic research due to the lack of robust transformation techniques. Current methods are often limited by tissue type and developmental constraints, hindering fu.....»»
Unveiling the molecular mechanisms linking aging with neurodegenerative diseases
Aging is the prime cause of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. But what exactly increases the prevalence of these brain disorders as one grows older? The molecular forces l.....»»
Cold-atom simulator demonstrates quantum entanglement between electronic and motional states
Researchers from the Institute for Molecular Science have revealed quantum entanglement between electronic and motional states in their ultrafast quantum simulator, generated by the repulsive force due to the strong interaction between Rydberg atoms......»»
Cells use alternative splicing to regulate gene expression, research suggests
Alternative splicing is a genetic process where different segments of genes are removed, and the remaining pieces are joined together during transcription to messenger RNA (mRNA). This mechanism increases the diversity of proteins that can be generat.....»»
Study combines data and molecular simulations to accelerate drug discovery
Researchers from the University of Cincinnati College of Medicine and Cincinnati Children's Hospital have found a new method to increase both speed and success rates in drug discovery......»»