Glucagon receptor structures uncover new arrestin interaction mechanism
G protein-coupled receptors (GPCRs) are essential for cell signal transduction and constitute the largest drug target protein family. Upon agonist stimulation, these receptors activate multiple downstream transducers, including G proteins and arresti.....»»
Malfunction in spermatogenesis: Researchers uncover contribution of cylicin proteins to male fertility
For successful fertilization, sperm should move forward rapidly and be shaped correctly. The unique structure of the sperm cells forms during spermiogenesis. Now, researchers from the University Hospital Bonn (UKB) and the Transdisciplinary Research.....»»
Researchers uncover battery-like functions of mitochondria using super-resolution microscopes
Using new super-resolution microscopes, researchers at the University of California, Irvine and the University of Pennsylvania have for the first time observed electrical charge and discharge functions inside mitochondria isolated from cells......»»
Study show extracellular vesicles can also deliver messages from non-human cells
Messenger bubbles produced by human cells can pick up bacterial products and deliver them to other cells, University of Connecticut researchers report in the Nov. 16 issue of Nature Cell Biology. The discovery may explain a key mechanism by which ba.....»»
Team discovers protein crucial for B cell differentiation and antibodies
A cell nucleus is a busy place. Cellular proteins twist and pull DNA, folding the genome into intricate 3D structures that support functioning of its coding parts......»»
Unlocking long-term genetic memory: Dormant bacterial spores offer key insights into evolutionary survival strategies
A recent study spearheaded by Prof. Sigal Ben Yehuda and her team at Hebrew University has unveiled a captivating facet of bacterial dormancy. Their research illuminates the mechanism through which dormant bacterial spores uphold and activate an endu.....»»
Forensic anthropologists work to identify human skeletal remains and uncover the stories of the unknown dead
A seasoned deer hunter is shocked when his hound dog trots up with a human femur clenched between its teeth. A woman veers off her normal urban walking path and happens upon a human skull. New property owners commission a land survey that reveals a s.....»»
Bioinspired self-assembled colloidal collectives of active matter systems
Active matter systems feature unique behaviors that include collective self-assembly structures and collective migration. However, the efforts to realize collective entities in spaces without wall-adhered support, in order to conduct three-dimensiona.....»»
Researchers identify "unicorn" defense mechanism that protects bacteria from antibiotics
Researchers at McMaster University have discovered unique characteristics of a mechanism used by bacteria to resist an important class of antibiotics. The new research, published in Nature Chemical Biology, shows that resistance to aminoglycoside dru.....»»
Combining extreme-ultraviolet light sources to resolve a quantum mechanical dissociation mechanism in oxygen molecules
For the first time, researchers have succeeded in selectively exciting a molecule using a combination of two extreme-ultraviolet light sources and causing the molecule to dissociate while tracking it over time. This is another step towards specific q.....»»
First experimental evidence of hopfions in crystals: Research opens up new dimension for future technology
Hopfions, magnetic spin structures predicted decades ago, have become a hot and challenging research topic in recent years. In a study published in Nature, the first experimental evidence is presented by a Swedish-German-Chinese research collaboratio.....»»
Study sheds new light on mechanism of robust motility of flagellated bacteria
Flagellated bacteria are propelled by the rotation of helical flagellar filaments, each with a flagellar motor at its base. Taking Escherichia coli (E. coli) as an example, each cell has 3–7 flagella whose rotation as a helical bundle enables the c.....»»
The formation of switchable and metastable discrete structures through chiral self-sorting
A paper titled "Thermo-/Mechano-Chromic Chiral Coordination Dimer: Formation of Switchable and Metastable Discrete Structure through Chiral Self-Sorting" describes chiral coordination dimers that emerge based on effectively exclusive chiral self-sort.....»»
Microautophagy is essential for preventing aging, finds lysosomes study
To age or not to age? How does aging affect organisms on a cellular level? What mechanisms help cells survive self-inflicted or external harm? It is known that lysosomes—critically important cellular structures—are crucial for digesting damaged c.....»»
Reshaping protein design with function-first, AI-guided engineering
A significant step forward in protein design from Generate Biomedicines, Massachusetts, has developed an AI that can generate feasible protein structures and predict the potential functionality of the proteins generated......»»
Archaeologists uncover Europe"s hidden Bronze Age megastructures
Archaeologists from University College Dublin, working with colleagues from Serbia and Slovenia, have uncovered a previously unknown network of massive sites in the heart of Europe that could explain the emergence of the continent's Bronze Age megafo.....»»
Sigma Synthetic Fraud v4 uncovers multiplex synthetic-specific features
Socure has launched Sigma Synthetic Fraud v4. The product uses advanced machine learning and diverse, third-party and network feedback data to uncover patterns linked to insidious synthetic identity fraud. The Deloitte Center for Financial Services e.....»»
Research reveals molecular mechanism of asymmetric calcium-sensitive receptor activation
Calcium-sensing receptors (CaSRs), widely distributed in tissues and organs such as parathyroid glands, intestines, bones and kidneys, sense the concentration of calcium ions in the blood and maintain the calcium balance in the human body. CaSR is so.....»»
Researchers tune the speed of chirality switching
Chiral molecules can have dramatically different functional properties while sharing identical chemical formulae and almost identical structures. The molecular structure of two types of a chiral molecule—so-called enantiomers—are mirror images of.....»»
All the best macOS Sonoma tips and tricks you need to know
Find out how to get more from macOS Sonoma and uncover some of its most useful features with these clever tips and tricks for Apple’s operating system......»»
Did this chemical reaction create the building blocks of life on Earth?
How did life begin? How did chemical reactions on the early Earth create complex, self-replicating structures that developed into living things as we know them?.....»»