Glucagon receptor structures uncover new arrestin interaction mechanism
G protein-coupled receptors (GPCRs) are essential for cell signal transduction and constitute the largest drug target protein family. Upon agonist stimulation, these receptors activate multiple downstream transducers, including G proteins and arresti.....»»
Trained AI system learns to design cellular materials for tissue engineering, energy storage
Artificial structures called cellular materials have a network of internal spaces within a solid cell-like matrix. Their porous foam-like architecture combines advantages of low density with strength. Researchers at the National Institute for Materia.....»»
Scientists uncover a new model for the effects of radiation in water systems
What happens when radiation hits water? This is a question that has an impact every time you get an X-ray at the doctor's office, given you are mostly made of water. A team of theoretical physicists at DESY has worked on data taken by colleagues from.....»»
Examining how molecular orbitals determine stability
Carboxylic acid dianions (fumarate, maleate, and succinate) play a role in coordination chemistry and, to some extent, also in the biochemistry of body cells. An HZB team at BESSY II has now analyzed their electronic structures using RIXS in combinat.....»»
Scientists reveal why blueberries are blue
Tiny external structures in the wax coating of blueberries give them their blue color, researchers at the University of Bristol can reveal. This applies to a lot of fruits that are the same color including damsons, sloes and juniper berries......»»
Q&A: Research visualizes a precise mechanism for how cells sort their trash
For decades it has been an open question in the ubiquitin research field how proteins are labeled as being defective or unneeded. In a recent study Brenda Schulman, Director at the Max Planck Institute (MPI) of Biochemistry, and Gary Kleiger, Chair o.....»»
Building a DNA nanoparticle to be both carrier and medicine
Scientists have been making nanoparticles out of DNA strands for two decades, manipulating the bonds that maintain DNA's double-helical shape to sculpt self-assembling structures that could someday have jaw-dropping medical applications......»»
Researchers uncover biological circuit that offers a new avenue for creating drought-resistant crops
Climate change is already harming agricultural yields and may one day pose a significant threat to the world's food supply. Engineering more resilient crops, including those able to thrive in the face of drought or high soil salinity levels, is an in.....»»
Plan for Europe"s huge new particle collider takes shape
Europe's CERN laboratory revealed more details Monday about its plans for a huge new particle accelerator that would dwarf the Large Hadron Collider (LHC), ramping up efforts to uncover the underlying secrets of the universe......»»
New research finds that young planets are flattened structures rather than spherical
Astrophysicists from the University of Central Lancashire (UCLan) have found that planets have flattened shapes like smarties just after they form rather than being spherical as previously thought......»»
Preclinical study uncovers two proteins" crucial role in causing cancer cell growth
Scientists at City of Hope, one of the largest cancer research and treatment organizations in the United States, have discovered a new cellular mechanism that plays an important role in cancer cells' ability to cause disease. The study is published i.....»»
Researchers uncover the architecture of poxvirus cores
A recent re-emergence and outbreak of mpox brought poxviruses back as a public health threat, underlining an important knowledge gap at their core. Now, a team of researchers from the Institute of Science and Technology Austria (ISTA) lifted the myst.....»»
Exploring new physics arising from electron interactions in semiconductor moiré superlattices
Semiconductor moiré superlattices are fascinating material structures that have been found to be promising for studying correlated electron states and quantum physics phenomena. These structures, made up of artificial atom arrays arranged in a so-ca.....»»
Our oldest microbial ancestors were way ahead of their time
Specialized internal structures were present over 1.5 billion years ago. Enlarge / The Golgi apparatus, shown here in light green, may have been involved in building internal structures in cells. (credit: ARTUR PLAWGO / SCIENCE P.....»»
Team discovers mechanism that protects tissue after faulty gene expression
A study at the University of Cologne's CECAD Cluster of Excellence in Aging Research has identified a protein complex that is activated by defects in the spliceosome, the molecular scissors that process genetic information. Future research could lead.....»»
How the social structures of Nazi Germany created a bystander society
In the initial post-war judicial proceedings to establish what had happened under Nazism, and to punish the perpetrators of crimes, victims' accounts were often discredited. Only in 1961, with the high-profile trial of Nazi war criminal Adolf Eichman.....»»
Researchers uncover source rocks of the first real continents
Geoscientists have uncovered a missing link in the enigmatic story of how the continents developed—a revised origin story that doesn't require the start of plate tectonics or any external factor to explain their formation. Instead, the findings pub.....»»
Gene expression influences 3D folding of chromosomes by altering structure of the DNA helix, finds study
A collaborative study by the UTokyo-KI LINK program, headed by Camilla Björkegren from Karolinska Institutet, Kristian Jeppsson and Katsuhiko Shirahige from The University of Tokyo shows that a protein complex named Smc5/6 binds DNA structures calle.....»»
Researchers discover molecular mechanism that influences the symmetrical shape of the style
Humans are attracted to symmetry: in our buildings, our gardens, in our potential partners. For plants, the symmetrical shapes of organs are a matter of survival because the form directly impacts the function......»»
A manifold fitting approach for high-dimensional data reduction beyond Euclidean space
Statisticians from the National University of Singapore (NUS) have introduced a new technique that accurately describes high-dimensional data using lower-dimensional smooth structures. This innovation marks a significant step forward in addressing th.....»»
To stick or not to stick? Mixed sand columns illuminate design of better materials
Scientists from Tokyo Metropolitan University have been studying the strength and toughness of sand columns made of a mixture of sticky and non-sticky grains. They have uncovered the mechanism behind how the strength changes as grains are mixed in di.....»»