Glucagon receptor structures uncover new arrestin interaction mechanism
G protein-coupled receptors (GPCRs) are essential for cell signal transduction and constitute the largest drug target protein family. Upon agonist stimulation, these receptors activate multiple downstream transducers, including G proteins and arresti.....»»
Scientists elucidate the role of GlyT1 in anti-schizophrenia drugs
Schizophrenia is a highly disabling mental disorder, and numerous studies have shown that the hypofunction of the N-methyl-d-aspartate (NMDA) receptor is one of its pathogenic mechanisms. Glycine transporter 1 (GlyT1), a glycine transporter protein,.....»»
Scientists uncover a causal relationship between remote extreme heat and the Canadian wildfires in 2023
Wildfires are events that can have significant impacts on ecosystems and human society. In the context of global warming, there has been a notable surge in the frequency and ferocity of wildfires in the Northern Hemisphere over recent years. In 2023,.....»»
Semgrep Assistant boosts AppSec team productivity using AI
Semgrep announced Semgrep Assistant, a tool that uses Artificial Intelligence (AI) to drive efficiencies and uncover insights across all phases of an AppSec program, from rule creation to remediation. Semgrep is a static code analysis tool that alert.....»»
Researchers identify key regulators underlying regeneration in Drosophila
Some animals possess the remarkable ability to regenerate lost structures, exemplified by a lizard regrowing its tail. However, this regenerative process must be tightly regulated by the body to ensure proper tissue organization and to prevent abnorm.....»»
Researchers explore how beluga whale melon changes shape during social interaction
A trio of animal science researchers at the University of Rhode Island, in the U.S., has identified five major shapes displayed by the beluga whale melon. For their study published in the journal Animal Cognition, Justin Richard, Isabelle Pellegrini,.....»»
Researchers develop 3D-printed wood from its own natural components
Researchers at Rice University have unlocked the potential to use 3D printing to make sustainable wood structures, offering a greener alternative to traditional manufacturing methods......»»
1% of users are responsible for 88% of data loss events
Data loss is a problem stemming from the interaction between humans and machines, and ‘careless users’ are much more likely to cause those incidents than compromised or misconfigured systems, according to Proofpoint. While organizations a.....»»
Researchers uncover culprits behind pitting corrosion in 3D-printed stainless steel
Like a hidden enemy, pitting corrosion attacks metal surfaces, making it difficult to detect and control. This type of corrosion, primarily caused by prolonged contact with seawater in nature, is especially problematic for naval vessels......»»
Alarm bells ring as scientists uncover major flaws in ability to track changes to global conservation areas
In a significant stride towards safeguarding global biodiversity, the Kunming-Montreal Global Biodiversity Framework (GBF) has set a target for nations to preserve 30% of the Earth by 2030......»»
Conduction of catalytic properties from buried transitional metals to exposed inert main group metals
The electronic interaction between buried single transitional metal and adjacent aluminum atoms via metallic bonding can be well demonstrated......»»
A 790,000 year-old asteroid impact could explain seafloor spherules
Our solar system does not exist in isolation. It formed within a stellar nursery along with hundreds of sibling stars, and even today has the occasional interaction with interstellar objects such as 'Oumuamua and Borisov. So it's reasonable to presum.....»»
Strong coordination interaction identified as being favorable for promoting ethanol dehydrogenation
Butadiene, one of the most important light olefins in the petrochemical industry with a global production capacity of 18 million metric tons per year, is currently produced through the extractive distillation of C4 fractions from naphtha steam cracki.....»»
Study shows for the first time that different forms of cellular adhesion structures can interconvert
Cells form adhesion structures to anchor themselves in their environment. The coordinated assembly and disassembly of these adhesions also enables cells to move from one place to another......»»
Researchers present "domino effect" sensing mechanism to detect amine approaching picomolar level
Accurate and sensitive detection of amines is crucial in industrial safety, environmental monitoring and clinical diagnosis. Ongoing research and development of sensing materials offer promise for enhancing the sensitivity and selectivity of amine de.....»»
A faster, cheaper way to synthesize diabetes and weight loss drugs like semaglutide
Semaglutide is part of the glucagon-like peptide-1 (GLP-1) receptor targeting family of peptide drugs which are mainly used to treat diabetes but are difficult and expensive to make......»»
What should we do with aging marine structures?
Marine artificial structures (MAS), such as oil and gas platforms and offshore wind farms, have a finite operational period and will eventually need to be decommissioned......»»
Unveiling inaoside A: An antioxidant derived from mushrooms
Natural products have unique chemical structures and biological activities and can play a pivotal role in advancing pharmaceutical science. In a study published in Heliyon, researchers from Shinshu University have discovered inaoside A, an antioxidan.....»»
Harnessing nature"s shield: Enhancing sun protection with lignin nanoparticles in cosmetics
Lignin nanoparticles (LNPs) have emerged as promising candidates for enhancing sun protection in cosmetics, offering superior UV-blocking capabilities compared to soluble lignin oligomers. However, the effects of the chemical structures of constituti.....»»
New biology unveiled for fundamental cellular machinery
Cellular communication relies on receptor molecules on the cell surface. The periodic uptake and sorting of these receptors, critical for their degradation or recycling, are governed by an elaborate machinery prominently featuring the Commander compl.....»»
New study discovers how altered protein folding drives multicellular evolution
Researchers have discovered a mechanism steering the evolution of multicellular life. They identify how altered protein folding drives multicellular evolution......»»