Fluorescent visualization and evaluation of NPC1L1-mediated cholesterol absorption at the levels of endocytic vesicles
Excessive cholesterol absorption from intestinal lumen contributes to the pathogenesis of hypercholesterolemia, which is a well-established risk factor for atherosclerotic cardiovascular disease. The absorption of intestinal cholesterol is primarily.....»»
Addressing global water security challenges: New study reveals investment opportunities and readiness levels
Water scarcity, pollution, and the burden of waterborne diseases are urgent issues threatening global health and security. A recently published study in the journal Global Environmental Change highlights the pressing need for innovative economic stra.....»»
Drought reduces Amazon River in Colombia by as much as 90%: report
The Amazon River has seen its levels in Colombia reduced by as much as 90 percent, a government agency said Thursday, as South America faces a severe and widespread drought......»»
KEF’s affordable new Q Series speakers get an audiophile upgrade
KEF has upgraded its Q Series speakers with its Metamaterial Absorption Technology (MAT), delivering high-end audiophile sound at a fair price......»»
A new approach for rockburst risk control and mitigation in deep mining
Mining of minerals is important for the advancement of modern society. However, over many years of mining, shallow resources are depleting with the need to migrate to deep levels......»»
Climate scientists sound alarm over Asia"s rising seas
Immediate action is needed at all levels to protect communities in the Asia Pacific from sea levels that are rising significantly faster than the global average, say climate scientists ahead of the next key UN climate summit......»»
Rising waters, waning forests: Scientists are using tree rings to study how rising sea levels affect coastal forests
Sunlight filters through the canopy of pines, holly, sweet gum, and red maple while bird calls echo in the distance. These coastal forests may seem like others in the Mid-Atlantic, but a hidden challenge looms. Standing tall next to their salt marsh.....»»
UN chief says sea level rise threatens "rising tide of misery"
United Nations Secretary-General Antonio Guterres warned on Wednesday that rising sea levels threaten to create "a rising tide of misery" for millions, with intense storm surges, coastal erosion and coastal flooding increasingly likely......»»
Violence, harassment from students is overwhelmingly "part of the job" for Saskatchewan education sector workers
Saskatchewan education sector workers are experiencing disturbing levels of workplace violence and harassment, says a new report spotlighting a situation that has reached "a breaking point," according to its authors......»»
Discovering new energy levels in atomic hyperfine structures
Since the late 1960s, the Laboratoire Aimé Cotton (LAC) in Orsay, France, has made significant progress in the classification of complex atomic spectra. These advances have been driven both by the development of Fourier transform spectroscopy, and t.....»»
Researchers uncover key insights into cholesterol"s structure in cell membranes
A new study by Rice University researchers led by Jason Hafner could open new pathways for understanding how cholesterol influences cell membranes and their receptors, paving the way for future research on diseases linked to membrane organization. Th.....»»
Compact "gene scissors" enable effective genome editing, may offer future treatment of high cholesterol gene defect
CRISPR-Cas is used broadly in research and medicine to edit, insert, delete or regulate genes in organisms. TnpB is an ancestor of this well-known "gene scissors" but is much smaller and thus easier to transport into cells......»»
Study reveals high rates of seafood mislabeling and ambiguous market names in Calgary, Alberta
A study published in PeerJ Life and Environment has uncovered alarming levels of seafood mislabeling and the use of ambiguous market names in Calgary's seafood market, often concealing species of conservation concern. This research marks the first Ca.....»»
New biosensor illuminates physiological signals in living animals
Eric Schreiter and Luke Lavis thought they had figured it out. In 2021, the Janelia group leaders reported that they had developed a way to combine Schreiter's engineered protein biosensors and Lavis's bright, fluorescent Janelia Fluor dyes......»»
Researchers identify novel endocytic recycling mechanism with "kiss-and-run" membrane fusion
Endocytosis and recycling control the uptake and retrieval of various materials in eukaryotic cells. Mammalian cells have developed several recycling routes, including the relatively extensively studied "fast" and "slow" tubulovesicular recycling pat.....»»
Study shows cholesterol enhances exosome-mediated RNA drug delivery
RNA interference (RNAi) technology has gradually become a cutting-edge technology for treating diseases such as genetic disorders and cancer due to its huge potential in gene expression regulation. However, the efficient delivery and safety of short.....»»
Moderate levels of exotic species invasions may help maintain biodiversity, study suggests
Globally, more than 13,000 plant species, equivalent to the entire native flora of Europe, have been naturalized outside their native ranges. A study, jointly conducted by scientists from China and the U.S., provides new insights about biodiversity,.....»»
New research re-envisions Earth"s mantle as a relatively uniform reservoir
Lavas from hotspots—whether erupting in Hawaii, Samoa or Iceland—likely originate from a worldwide, uniform reservoir in Earth's mantle, according to an evaluation of volcanic hotspots published in Nature Geoscience......»»
DNA origami and fluorescent probes can precisely release molecular cargo
In the world of nanotechnology, the development of dynamic systems that respond to molecular signals is becoming increasingly important. The DNA origami technique, whereby DNA is programmed so as to produce functional nanostructures, plays a key role.....»»
Will customers accept less meat in their cafeteria meals?
Meat consumption in industrial nations is much too high and this not only increases the risk of e.g. cardiovascular diseases. Increasing levels of animal husbandry also aggravate the global food problem because the cultivation of animal feed uses val.....»»
‘I’m a Cardiologist, and This Is the #1 Most Important Thing To Do if You Know You’re at Risk for High Cholesterol"
‘I’m a Cardiologist, and This Is the #1 Most Important Thing To Do if You Know You’re at Risk for High Cholesterol".....»»