CRISPR now possible in cockroaches
Researchers have developed a CRISPR-Cas9 approach to enable gene editing in cockroaches, according to a study published by Cell Press on May 16th in the journal Cell Reports Methods. The simple and efficient technique, named "direct parental" CRISPR.....»»
New CRISPR-based tool inserts large DNA sequences at desired sites in cells
Building on the CRISPR gene-editing system, MIT researchers have designed a new tool that can snip out faulty genes and replace them with new ones, in a safer and more efficient way......»»
Genetic "hitchhikers" can be directed using CRISPR
In a new study, North Carolina State University researchers characterize a range of molecular tools to rewrite—not just edit—large chunks of an organism's DNA, based on CRISPR-Cas systems associated with selfish genetic "hitchhikers" called trans.....»»
How researchers used CRISPR gene editing to send immune cells after cancer
New trial has limited effect on cancer, but technology is likely to see further use. (credit: Lawrence Berkeley National Labs) Last week, researchers published the results of a clinical trial that used CRISPR gene editin.....»»
They"re doing their best: How these 3 neighborhood "pests" deal with rainy days
Have you had a recent encounter with an animal you'd much rather avoid? As La Niña continues to give us rainy days, brush turkeys, bats, and cockroaches are emerging from their hide-outs......»»
New study finds that CRISPR/Cas9 leads to unexpected genomic changes
The widely used gene scissor (CRISPR/Cas) can modify the genetic content in cells to study the molecular roles of genes and has gained great clinical relevance in gene therapy to treat genetic diseases. A new study performed by Claudia Kutter's resea.....»»
This Personalized Crispr Therapy Is Designed to Attack Tumors
In a small study, researchers modified patients’ immune cells to target their particular cancer—but it only worked for a third of volunteers......»»
A new control system for synthetic genes
Using an approach based on CRISPR proteins, MIT researchers have developed a new way to precisely control the amount of a particular protein that is produced in mammalian cells......»»
Breakthrough in CRISPR research may lead to more effective and safer gene editing
10 years ago we saw a breakthrough in modern biology......»»
Researchers make cyborg cockroaches that carry their own power packs
Solar cell and a battery can keep the cyborg's electronics running for weeks. Enlarge (credit: Kenjiro Fukuda, RIKEN) Have you ever thought you’d be seeing a cyborg cockroach that runs on solar power and carries a backpack t.....»»
New CRISPR-Cas approach permits more precise DNA cleavage
A team led by investigators at Massachusetts General Hospital (MGH) has overcome a major constraint for cutting and editing DNA by CRISPR-Cas enzymes and other technologies. The recent innovation, which is published in Nature Biotechnology, will simp.....»»
New gene-editing platform broadens scope of use of CRISPR gene editing
A team of researchers at Northwestern University has devised a new platform for gene editing that could inform the future application of a near-limitless library of CRISPR-based therapeutics......»»
A bold effort to cure HIV—using Crispr
Key is whether the gene-editing technology can stop the virus from replicating. Enlarge / A 3D illustration of the HIV virus. (credit: Westend61 / Getty) In July, an HIV-positive man became the first volunteer in a clinical tr.....»»
A Bold Effort to Cure HIV—Using Crispr
An experiment tests whether the gene-editing technology can stop the virus from replicating, which would ultimately wipe out the infection......»»
There’s New Proof Crispr Can Edit Genes Inside Human Bodies
The technique had largely been limited to editing patients’ cells in the lab. New research shows promise for treating diseases more directly......»»
Extracting the secrets of secondary metabolites
Microbial secondary metabolites, those molecules not essential for growth yet essential for survival, may now be easier to characterize following a proof-of-concept study in which researchers paired CRISPR and CRAGE technologies......»»
CRISPR-based technology targets global crop pest
Applying new CRISPR-based technology to a broad agricultural need, researchers at the University of California San Diego have set their aims on a worldwide pest known to decimate valuable food crops......»»
Scientists discover new antiviral defense system in bacteria
Bacteria use a variety of defense strategies to fight off viral infection, and some of these systems have led to groundbreaking technologies, such as CRISPR-based gene-editing. Scientists predict there are many more antiviral weapons yet to be found.....»»
Gene editing via CRISPR/Cas9 can lead to cell toxicity and genome instability
CRISPR/Cas9 is a precise gene editing technique whose development by Jennifer A. Doudna and Emmanuelle Charpentier was recognized with the 2020 Nobel Prize in Chemistry. Commonly known as "genetic scissors," CRISPR allows the introduction of the desi.....»»
A potential danger of CRISPR gene editing—and why base editing may be safer
Gene therapy using CRISPR/Cas9 gene editing is currently in clinical trials around the world for a variety of diseases. A report from Boston Children's Hospital, published June 27 in Nature Communications, warns of a potential, previously undiscovere.....»»
"Soft" CRISPR may offer a new fix for genetic defects
Curing debilitating genetic diseases is one of the great challenges of modern medicine. During the past decade, development of CRISPR technologies and advancements in genetics research brought new hope for patients and their families, although the sa.....»»