Class II PI3K lipid kinase: Structure of novel antithrombotic drug target resolved
Phosphatidylinositol 3-kinase, or PI3K for short, is a family of lipid kinases that plays a key role in the human body, performing functions such as cell division, metabolism, and cell growth......»»
Over half of Americans say lowering health care costs is among most important issues in deciding their presidential pick
Lowering the cost of health care and prescription drug prices and protecting Medicare and Social Security are among the most important issues for Americans in determining their vote for president, according to a new national West Health-Gallup Poll r.....»»
SCCMSecrets: Open-source SCCM policies exploitation tool
SCCMSecrets is an open-source tool that exploits SCCM policies, offering more than just NAA credential extraction. SCCM policies are a key target for attackers in Active Directory environments, as they can expose sensitive technical information, incl.....»»
Geologists discover mysterious subduction zone beneath Pacific, reshaping understanding of Earth"s interior
University of Maryland scientists uncovered evidence of an ancient seafloor that sank deep into Earth during the age of dinosaurs, challenging existing theories about Earth's interior structure. Located in the East Pacific Rise (a tectonic plate boun.....»»
Anti-bullying, sexual harassment resources increase in US schools but gaps remain
While violence prevention education has increased in U.S. schools, only one in 10 schools today require violence prevention discussions in class, according to research presented during the American Academy of Pediatrics 2024 National Conference & Exh.....»»
These 3D-printed pipes inspired by shark intestines outperform Tesla valves
Prototypes control fluid flow in a preferred direction with no need for moving parts. Enlarge / Shark intestines are naturally occurring Tesla valves; scientists have figured out how to mimic their unique structure. (credit: Sara.....»»
OpenAI drops nonprofit status in large-scale reorganization
OpenAI is reportedly planning to scrap the nonprofit structure of its core business in favor of a for-profit model that will be more attractive to investors......»»
AI trained on evolution"s playbook develops proteins that spur drug and scientific discovery
A new artificial intelligence model developed by researchers at The University of Texas at Austin paves the way for more effective and less toxic treatments and new preventive strategies in medicine. The AI model informs the design of protein-based t.....»»
How social structure influences the way people share money
People around the globe often depend on informal financial arrangements, borrowing and lending money through social networks. Understanding this sheds light on local economies and helps fight poverty......»»
Biologists sequence proteins by pulling them through nanopores
A team of chemical biologists at the University of Washington, working with colleagues at Oxford Nanopore Technologies, has developed a protein sequencing process that involves pulling proteins through nanopores in a lipid membrane. Their paper is pu.....»»
Advancing synthetic Ephedra-type alkaloids with a two-step enzymatic approach
Ephedra-type alkaloids, a class of naturally occurring compounds derived from plants in the genus Ephedra, have long held interest in the pharmaceutical industry due to their stimulant and airway widening effects. These alkaloids are used for the tre.....»»
Neutron experiments settle 40-year debate on enzyme for drug design
In just two neutron experiments, scientists discovered remarkable details about the function of an enzyme that can aid drug design for aggressive cancers......»»
Q&A: What"s behind the ban on cell phones in K-12 schools?
This school year, many of the nation's adolescents and teens are sitting in class without the device that can sometimes feel like an added appendage: their smartphones......»»
Researchers uncover key insights into cholesterol"s structure in cell membranes
A new study by Rice University researchers led by Jason Hafner could open new pathways for understanding how cholesterol influences cell membranes and their receptors, paving the way for future research on diseases linked to membrane organization. Th.....»»
Hybrid RV with a solar roof can power your home in an emergency
The hybrid powertrain has a range of 500 miles. Enlarge / This is Thor and Harbinger's test bed for a new Class A hybrid RV. (credit: Thor) Electrification is moving through different parts of the automotive industry at.....»»
Dealerships can start filing claims in CDK antitrust settlement
An Illinois federal judge has granted preliminary approval for CDK's agreement to pay $100 million to resolve a class-action antitrust lawsuit......»»
Gun violence in Philadelphia plummeted in 2024—researchers aren"t sure why, but here are 3 factors at play
Philadelphia experienced a surge in shootings and homicides during the COVID-19 years that disproportionately affected young Black and Latino men in economically disadvantaged neighborhoods with drug markets......»»
Can our stockpiles of Tamiflu protect against a bird flu pandemic?
Governments are banking on this old drug in the event of an H5N1 outbreak. Enlarge / A box and a tablet of Roche Pharmaceuticals' Tamiflu pills for influenza. (credit: Nikos Pekiaridis/NurPhoto via Getty Images) Since re.....»»
Chemists discover new ways in which single-celled organisms organize their DNA
It has only recently been discovered that single-celled organisms (bacteria and archaea) also have histones—proteins that structure DNA. Now, Leiden Ph.D. candidate Samuel Schwab has found that the histones in these organisms are much more diverse.....»»
From chaos to order: Proteins can re-structure themselves to create important substances
The protein "MIPS" changes its internal structure when it becomes active. Its disordered active center becomes a defined structure with special functions. The protein plays a key role in the production of inositol, which is also known as vitamin B8,.....»»
Proof-of-concept study uses X-rays to target mock-up asteroids in a vacuum
An X-ray pulse may be able to vaporize the surface of an asteroid and change its trajectory, according to a proof-of-concept paper published in Nature Physics. A laboratory experiment that mimics the deflection of an asteroid model using this techniq.....»»