Breakthrough identification of proteins necessary for muscle regeneration
A researcher at the University of Houston College of Pharmacy has identified the proteins necessary for efficient regeneration of skeletal muscles after acute injury and in Duchenne Muscular Dystrophy (DMD). Ashok Kumar, Else and Philip Hargrove Endo.....»»
Nanopore technique shows transport mechanism of chaperone proteins at the single-molecule level
Proteins control most of the body's functions, and their malfunction can have severe consequences, such as neurodegenerative diseases or cancer. Therefore, cells have mechanisms in place to control protein quality......»»
AI and quantum mechanics team up to accelerate drug discovery
Drug discovery is much like working a jigsaw puzzle. The chemical compounds behind drug molecules must be shaped to fit with the proteins in our bodies to produce therapeutic effects. That requirement for a meticulous fit means the creation of new dr.....»»
Physicists and psychologists track social phases in human movement
Observations of preschool children in classrooms and playgrounds have uncovered new social phases in human movement. Employing ultra-wideband radio frequency identification (UWB-RFID) technology allows for the precise tracking of children's movements.....»»
Study identifies compounds that extend longevity of Japanese morning glory flowers
The longevity of plant flowers is controlled by genetically programmed mechanisms. After a certain amount of time after flowering, the expression of genes associated with programmed cell death is induced and cellular components such as proteins and n.....»»
"Tough and uncompromising" training capable of transforming social work culture
Described as "tough and uncompromising", Grit Breakthrough Programs uses intensive group workshops and individual coaching to challenge assumptions, attitudes, and expectations, with the aim of helping participants break through self-imposed limitati.....»»
Ancient protein structure may have enabled early molecular evolution and diversification
In a finding that offers fresh insights into the early evolution of life on Earth, two RIKEN biologists have conducted lab experiments that have revealed a previously unknown protein fold, which is completely absent in modern proteins......»»
Filament structure found to activate and regulate CRISPR-Cas "protein scissors"
CRISPR-Cas systems help to protect bacteria from viruses. Several different types of CRISPR-Cas defense systems are found in bacteria, which differ in their composition and functions. Among them, the most studied proteins today are Cas9 and Cas12, al.....»»
Developing novel chiral capsule tools for advanced optical technologies
Chirality is an essential property in biology; the molecular building blocks of some of the most important biological structures, including DNA and proteins, are chiral. When a molecule is said to be chiral, it means that it is distinguishable from i.....»»
Planning a drug"s route in the body with synthetic chemistry
Researchers at the RIKEN Cluster for Pioneering Research (CPR) have developed technology that can alter, within the body, the recognized identity of proteins......»»
Research provides new insights into role of mechanical forces in gene expression
The genome inside each of our cells is modeled by tension and torsion—due in part to the activity of proteins that compact, loop, wrap and untwist DNA—but scientists know little about how those forces affect the transcription of genes......»»
Seeing double: Designing drugs that target "twin" cancer proteins
Some proteins in the human body are easy to block with a drug; they have an obvious spot in their structure where a drug can fit, like a key in a lock. But other proteins are more difficult to target, with no clear drug-binding sites......»»
Developing artificial muscles to give weakened people their strength back
Researchers have succeeded in making artificial muscle fibers from rubber thread, paving the way for sewing the muscles into a blouse and giving renewed strength to the wearer......»»
Fluorescent molecules to illuminate life: Simplified synthesis with formaldehyde
A research team has recently made a breakthrough in synthesizing organic fluorophores more cost-effectively and atom-efficiently than ever before by using formaldehyde, the simplest carbon molecule. Their findings were published in Angewandte Chemie.....»»
New tool can assess elderly dogs" frailty
Researchers from North Carolina State University have developed a tool that can aid owners and veterinarians in assessing an elderly dog's frailty. The tool—when coupled with simple assessments of body and muscle condition by the veterinarian—can.....»»
Scientists identify structural basis of stitched-together protein complexes that recycle most proteins in cells
Scientists at Sanford Burnham Prebys have developed a clearer picture of how crucial machinery in the human cell's recycling process for obsolete and misshapen proteins—known as proteasomes—are formed......»»
New research could extend the lifetime of key carbon-capture materials
Researchers at Lawrence Livermore National Laboratory (LLNL), in collaboration with the Georgia Institute of Technology, have made a significant breakthrough in understanding the impact of carbon dioxide (CO2) on the stability of amine-functionalized.....»»
Lignin-based sunscreen offers natural and high-performance UV protection
In a significant breakthrough for the cosmetics industry, researchers have developed a new type of sunscreen using lignin, a naturally abundant polymer, and titanium dioxide (TiO2). The study, led by Yarong Li and Zhiguang Tang, was published in the.....»»
Dead coral skeletons hinder reef regeneration by sheltering seaweed
The structural complexity of coral reefs creates a vibrant underwater city populated by a diverse assortment of characters. Ironically, this same complexity can impede coral recovery after disturbances......»»
AI trained on evolution"s playbook develops proteins that spur drug and scientific discovery
A new artificial intelligence model developed by researchers at The University of Texas at Austin paves the way for more effective and less toxic treatments and new preventive strategies in medicine. The AI model informs the design of protein-based t.....»»
Biologists sequence proteins by pulling them through nanopores
A team of chemical biologists at the University of Washington, working with colleagues at Oxford Nanopore Technologies, has developed a protein sequencing process that involves pulling proteins through nanopores in a lipid membrane. Their paper is pu.....»»