Activation of prodrug using protein-encased gold catalyst
As part of their efforts to devise ways to minimize the side effects of drugs for treating cancer, four RIKEN chemists have found a biocompatible way to convert compounds with low biological activity into anticancer drugs at tumors1......»»
Improving industrial scale lactoferrin production with synthetic biological systems
Lactoferrin (LF), a multifunctional glycoprotein of the transferrin family, is naturally expressed in human and cow milk. The name "LF" is derived from its ability to bind to iron (ferrin, a suffix indicating iron-binding protein)......»»
Strategies for maximizing recombinant protein production in tobacco plants
Plant molecular farming (PMF) is a modern, sophisticated technology that utilizes plants' biosynthetic machinery to synthesize a plethora of recombinant proteins, including industrial and therapeutic enzymes. It has several advantages over traditiona.....»»
The Pogues are back in the gold game in the Outer Banks season 4 trailer
After finding the lost city of El Dorado, the Pogues set out on another dangerous treasure hunt in the Outer Banks season 4 trailer......»»
Naked mole-rat found to have lost infection-resistant proteins
Scientists have found that the naked mole-rat—an underground rodent that lives up to 40 years—has lost a number of CD1 functional genes. The CD1 gene family in mammals is responsible for protein synthesis that protects the body against infectious.....»»
Increasing protein in staple crops could help alleviate global protein shortage
A Mississippi State biologist's research in improving global nutrition and sustainability is featured this week in New Phytologist......»»
From chaos to order: Proteins can re-structure themselves to create important substances
The protein "MIPS" changes its internal structure when it becomes active. Its disordered active center becomes a defined structure with special functions. The protein plays a key role in the production of inositol, which is also known as vitamin B8,.....»»
New biosensor illuminates physiological signals in living animals
Eric Schreiter and Luke Lavis thought they had figured it out. In 2021, the Janelia group leaders reported that they had developed a way to combine Schreiter's engineered protein biosensors and Lavis's bright, fluorescent Janelia Fluor dyes......»»
Better than blood tests? Nanoparticle potential found for assessing kidneys
In a study published July 29 in Advanced Materials, University of Texas at Dallas researchers found that X-rays of the kidneys using gold nanoparticles as a contrast agent might be more accurate in detecting kidney disease than standard laboratory bl.....»»
New method developed to relocate misplaced proteins in cells
Cells are highly controlled spaces that rely on every protein being in the right place. Many diseases, including cancers and neurodegenerative disorders, are associated with misplaced proteins. In some cancers, for instance, a protein that normally s.....»»
Double-edged STING: A new pathway involved in aging
A protein called STING, previously shown to control a pathway that contributes to antiviral signaling, also plays an important role in cellular stress clearance and cell survival, according to a new paper published in Molecular Cell......»»
Explaining dramatic planetwide changes after world"s last "Snowball Earth" event
Some of the most dramatic climatic events in our planet's history are "Snowball Earth" events that happened hundreds of millions of years ago, when almost the entire planet was encased in ice up to 0.6 miles (1 kilometer) thick......»»
Plant pathogen battle: A tomato protein"s dual role in defense and susceptibility
Tomatoes, a staple crop worldwide, are increasingly threatened by biotic stressors such as viruses, fungi, and bacteria, with the effects worsening under climate change. These challenges lead to reduced yields and compromised nutritional quality, hig.....»»
Silencing in action: How cells "repress" genomic remnants of ancient viruses
Researchers have identified key cellular control sites that regulate gene expression and prevent the activation of "cryptic" genomic regions, including ancient viral sequences......»»
Emily Gold, Cheerleader Featured on ‘America’s Got Talent,’ Dies by Suicide at 17
Emily Gold, Cheerleader Featured on ‘America’s Got Talent,’ Dies by Suicide at 17.....»»
Europa Clipper: 8 things to know about NASA"s mission to an ocean moon of Jupiter
The first NASA spacecraft dedicated to studying an ocean world beyond Earth, Europa Clipper aims to find out whether the ice-encased moon Europa could be habitable......»»
An unexpected protein connection in maize growth and defense could enhance crop resilience
Maize (corn) is one of the most important staple crops in the world and has been extensively studied. Yet, many aspects of the genetic mechanisms regulating its growth and development remain unexplored......»»
Team discovers naturally occurring DNA-protein hybrids
Thanks to a serendipitous discovery and a lot of painstaking work, scientists can now build biohybrid molecules that combine the homing powers of DNA with the broad functional repertoire of proteins—without having to synthesize them one by one, res.....»»
Restoration in the temple of Edfu reveals new inscriptions, paint, and gold
Egyptian temples were not only colorful, but also gleamed in glistening gold. Columns, gates and obelisks have been covered in gold since the beginning of the Pharaonic Period. Researchers also know from textual sources that some of the buildings wer.....»»
Scientists discover how TGF-Beta sends its message even while tethered to the cell membrane
For years, scientists have thought that TGF-Beta, a signaling protein that holds sway over an astonishing array of cellular processes from embryonic development to cancer, could only do its work once it escaped a lasso-like "straitjacket.".....»»
Edible insects show promise as sustainable nutritional source
As the global population grows and traditional livestock production increasingly strains environmental resources, there is a rising interest in alternative protein sources. Edible insects, particularly grasshoppers, are abundant in regions like Camer.....»»