Pulling the plug on viral infections: CRISPR isn"t just about cutting
CRISPR claimed scientific fame for its ability to quickly and accurately edit genes. But, at the core, CRISPR systems are immune systems that help bacteria protect themselves from viruses by targeting and destroying viral DNA and RNA. A new study pub.....»»
Study reveals the 3D structure of a protein involved in genome editing
Gene editing is one of the latest breakthroughs in biology. The widely known CRISPR-Cas gene editing system provided prokaryotes (organisms that lack cell nuclei) an immunity against foreign DNA. Since the discovery of the CRISPR gene editing technol.....»»
What should we call evolution driven by genetic engineering? Genetic welding, says researcher
With CRISPR-Cas9 technology, humans can now rapidly change the evolutionary course of animals or plants by inserting genes that can easily spread through entire populations. Evolutionary geneticist Asher Cutter proposes that we call this evolutionary.....»»
It’s Official: No More Crispr Babies—for Now
In the face of safety risks, experts have tightened the reins on heritable genome editing—but haven’t ruled out using it someday......»»
Machine learning helps determine success of advanced genome editing
A new tool to predict the chances of successfully inserting a gene-edited sequence of DNA into the genome of a cell, using a technique known as prime editing, has been developed by researchers at the Wellcome Sanger Institute. An evolution of CRISPR-.....»»
Using CRISPR-Cas9 to knock out asparagine gene in wheat to reduce cancer risk
A team of biologists from Rothamsted Research, the University of Bristol and Curtis Analytics Limited—all in the U.K.—has used the CRISPR-Cas9 gene editing system to knock out the asparagine gene in wheat grown in real-world conditions—part of.....»»
Modified CRISPR/Cas9 gene editing system used to learn more about the evolution of giant viruses
A team of virologists at Aix–Marseille University, has found evidence that suggests the giant virus Pandoravirus neocaledonia evolved from smaller and simpler viruses. In their study, published in the journal Nature Communications, the group used a.....»»
When editing bacteria with CRISPR, less is more
Systematically attenuating DNA targeting activity can achieve CRISPR-driven editing in bacteria, greatly boosting colony counts and even increasing the frequency of precise genome editing. This was shown in a study of the Helmholtz Institute Würzbur.....»»
Research team establishes cell lines to improve iPSC research
Induced Pluripotent Stem Cell (iPSC) lines have become essential for determining the underlying genetic drivers of human disease. Genomes of iPSCs can be easily edited using the bacteria-based CRISPR/Cas9 technology to introduce or correct disease-as.....»»
What is CRISPR? What to know about the transformative gene-editing tool
Over the past 10 years, CRISPR has been transformative for research, enabling gene editing that is fast, simple and precise, experts say......»»
Researchers create new system for safer gene-drive testing and development
Scientists continue to expand the technological frontiers of CRISPR, along with its enormous potential, in areas ranging from human health to global food supplies. Such is the case with CRISPR-based gene drives, a genetic editing tool designed to inf.....»»
Modified CRISPR-based enzymes improve the prospect of inserting entire genes into the genome
Many genetic diseases are caused by diverse mutations spread across an entire gene, and designing genome editing approaches for each patient's mutation would be impractical and costly......»»
Biochemists describe structure and function of newly discovered CRISPR immune system
Utah State University biochemists Thomson Hallmark and Ryan Jackson, along with collaborators, published two seminal papers this week. Their findings describe the structure and function of a newly discovered CRISPR immune system that—unlike better-.....»»
2.6 billion-year-old ancestors of the CRISPR gene-editing tool are resurrected
An international research group has for the first time reconstructed ancestors dating back 2.6 billion years of the well-known CRISPR-Cas system, and studied their evolution over time. The results suggest that the revitalized systems not only work, b.....»»
Breakthrough in plant breeding: Grafting and mobile CRISPR for genome editing in plants
A ground-breaking twist to the CRISPR tool—aka "genetic scissors"—is being put to use to edit plant genomes by scientists from the Max Planck Institute of Molecular Plant Physiology, signaling a methodology change. The discovery, recently publish.....»»
CRISPR’s quest to slay Donegal Amy
Trial hints at treating, or even curing, a rare fatal disease Enlarge (credit: Yasmin Monet Butcher/Jacqui Vanliew/Getty Images) In the 5th century, in early medieval Ireland, Conall Gulban, an Irish king, gave his name.....»»
Crispr’s Quest to Slay Donegal Amy
A trial using the gene-editing tool inside the body hints at treating, or even curing, a rare fatal disease—and is changing a community in the process......»»
The Crispr Baby Scientist Is Back. Here’s What He’s Doing Next
He Jiankui discusses his plans for finding cures for devastating genetic diseases. Should the scientific community trust him?.....»»
How to edit the genes of nature"s master manipulators
CRISPR, the Nobel Prize-winning gene editing technology, is poised to have a profound impact on the fields of microbiology and medicine yet again......»»
New CRISPR-based tool inserts large DNA sequences at desired sites in cells
Building on the CRISPR gene-editing system, MIT researchers have designed a new tool that can snip out faulty genes and replace them with new ones, in a safer and more efficient way......»»