In children with multiple sclerosis, teriflunomide tempers lesion growth
A phase 3 clinical trial tested the safety and efficacy of teriflunomide, an oral immunomodulatory drug, in children with multiple sclerosis. Although the medication did not prevent disease relapses to a greater extent than placebo, the option for so.....»»
Global HIV viral suppression rates too low among children and adolescents
An analysis in the lead up to World AIDS Day reveals that HIV is 'virally suppressed' in only 59 per cent of children and adolescents on treatment......»»
Correcting inherited gene alterations speeds up
Researchers have developed a method to precisely and rapidly correct genetic alterations in the cultured patient cells......»»
Potential new treatment for Alzheimer’s disease would be relatively cheap
Researchers have discovered a protein involved in the development of Alzheimer's disease. Studies in mice showed that eliminating this protein entirely or using drugs to block its function reduced physical changes in the brain associated with the dis.....»»
Early interventions could help counteract muscle loss
Weakening muscles are a natural part of the aging process, but for some people with a condition called sarcopenia the decline is abnormally fast. A new study suggests that the early stages of sarcopenia could be counteracted with timely interventions.....»»
Researchers model circadian clock neurons in a day-active animal
It's no secret that jet lag and night-shift work can wreak havoc on the way our body's internal clock syncs up our daily wake-sleep cycle, known as circadian rhythm, but now researchers say they are a step closer to understanding how the brain create.....»»
Rates of type 2 diabetes are higher in people with one of various common psychiatric disorders
A new study finds that the prevalence of type 2 diabetes (T2D) is elevated in people with a psychiatric disorder compared with the general population......»»
Telehealth-delivered diet and exercise program eased knee pain and triggered weight loss
Combined diet and exercise Telehealth program saw 80 per cent of participants experience reduced knee pain with an average weight loss of approximately 10.2 per cent......»»
Heart repair and regeneration after a heart attack
Twenty years ago, clinicians first attempted to regenerate a failing human heart by injecting muscle myoblasts into the heart during a bypass operation. Despite high initial hopes and multiple experimental and clinical studies since then, outcomes ha.....»»
De-cluttering may not help people with dementia
A clutter-free environment may not help people with dementia carry out daily tasks -- according to a new study. Researchers studied whether people with dementia were better able to carry out tasks, such as making a cup of tea, at home - surrounded by.....»»
Which glioblastoma patients will respond to immunotherapy?
Scientists have discovered a new biomarker to identify which patients with brain tumors called glioblastomas -- the most common and malignant of primary brain tumors -- might benefit from immunotherapy. The treatment could extend survival for an esti.....»»
Steam disinfection of baby bottle nipples exposes babies and the environment to micro- and nanoplastic particles
Using a new microspectroscopic technique, scientists have found that steam disinfection of silicone-rubber baby bottle nipples exposes babies and the environment to micro- and nanoplastic particles......»»
"Transformational" approach to machine learning could accelerate search for new disease treatments
Researchers have developed a new approach to machine learning that 'learns how to learn' and out-performs current machine learning methods for drug design, which in turn could accelerate the search for new disease treatments......»»
How obesity damages the skeletal muscle metabolism
A decline in metabolism and endurance of skeletal muscle is commonly observed in obese patients, but the underlying mechanism is not well-understood. A research team uncovers a new mechanism to explain how obesity jeopardizes the functions of skeleta.....»»
Getting the most therapeutic potential out of cells
A simple change in the way donor cells are processed can maximize a single cell's production of extracellular vesicles, which are small nanoparticles naturally secreted by cells, according to new research......»»
A tough attachment between rotator cuff, bone achieved through unique fibrous architecture
Researchers used a novel imaging technique and discovered a previously unknown fibrous architecture between the rotator cuff tendons and their bony attachments in the shoulder......»»
Scientists discover potential cause of Alzheimer’s Disease
In people with brain buildups, a key but difficult-to-detect difference in the form of tau protein allows scientists to distinguish people showing no outward signs of dementia from those who do......»»
Method to reveal undesired biological effects of chemicals
How do pollutants and other chemicals that we are exposed to affect our health? Researchers have applied a method to identify the proteins in the body affected by chemicals. The method can be used to discover at an early stage whether a substance has.....»»
This is how the superbug Pseudomonas aeruginosa reacts to antibiotics
The bacterium Pseudomonas aeruginosa is resistant to all antibiotics on the market. Therefore, there is a great need for new therapeutic approaches. In order to find them, it helps to understand how the germ reacts to active substances......»»
Scientists produce new antibiotics by gene editing
Scientists have discovered a new route to produce complex antibiotics exploiting gene editing to re-program pathways to future medicines urgently required to combat antimicrobial resistance, treat neglected diseases and prevent future pandemics......»»