Unfreezing waters in ligand binding sites to aid in drug discovery
Cryogenic (frozen) protein structures are central to understanding function and developing drugs. Scientists at St. Jude Children's Research Hospital have created an algorithm to reveal when freezing the proteins may create "artifacts,"—errors that.....»»
Lost lake sheds light on past and future water security
Nestled high in the Eastern Lesotho Highlands, scientists have uncovered fascinating evidence of an ancient mountain lake that flourished thousands of years ago. This discovery, made by Professor Jennifer Fitchett from the University of the Witwaters.....»»
Research team develops new antimalarial agent for combating drug-resistant parasites
Malaria remains a serious health issue globally, especially in Africa. The disease is caused by protozoan parasites in the Plasmodium genus. In 2021, there were 247 million cases of malaria and 619,000 deaths reported worldwide......»»
A new way to make element 116 opens the door to heavier atoms
Scientists at the Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) are credited in the discovery of 16 of the 118 known elements. Now they've completed the crucial first step to potentially create yet another: element 120......»»
Counter-drug strategies in Central America are worsening deforestation, threatening many species of birds
Activities associated with cocaine trafficking threaten two-thirds of the most important landscapes in Central America for 196 forest bird species, including 67 migratory species. This is the key takeaway from a study that colleagues and I published.....»»
Lunar exploration ground sites will enhance the Near Space Network"s communications services
NASA's LEGS can do more than help Earthlings move about the planet. Three Lunar Exploration Ground Sites, or LEGS, will enhance the Near Space Network's communications services and support of NASA's Artemis campaign......»»
Physicists uncover key to resolving long-standing inertial confinement fusion hohlraum drive deficit
A team of researchers at Lawrence Livermore National Laboratory (LLNL) has made advancements in understanding and resolving the long-standing "drive-deficit" problem in indirect-drive inertial confinement fusion (ICF) experiments. This discovery coul.....»»
Porsche waters down EV ambitions, says transition will take "years"
German automaker is latest to warn that goals set in recent years for future EV sales were too ambitious as customers remain reticent to make the switch away from gasoline-powered cars......»»
Discovery of daphnane diterpenoids in Daphne pedunculata could lead to new HIV drugs
A research group led by Professor Wei Li of the Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Toho University, in collaboration with Shenyang Pharmaceutical University in China and Duke University Medical Center in the United State.....»»
New date for Earth"s largest iron deposits offers clues for future exploration
Research led by Curtin University reveals that Earth's largest iron ore deposits—in the Hamersley Province of Western Australia—are about one billion years younger than previously believed, a discovery which could greatly boost the search for mor.....»»
Discovery of Piezo1"s new signaling mechanism may aid search for better pain and itch treatments
The human body's sense of touch is so important it can be found throughout the body, not just on the skin. Two tiny sensors of touch, Piezo1 and Piezo2, signal the lightest pressures and can be found monitoring the circulatory system, telling the bod.....»»
Illegal drug found in Diamond Shruumz candies linked to severe illnesses
New testing finds psilocin, related to psilocybin, in gummies purchased in 2023. Enlarge (credit: Diamond Shruumz) Newly released testing data of Diamond Shruumz-brand gummies purchased in 2023 identified the presence of.....»»
Moonlit scramble across the sand for Turkey"s booming baby turtle population
The baby loggerhead sea turtles emerged from their eggshells and began their first challenge in life: a wobbly dash across the sand to the moonlit waters of Turkey's Mediterranean coast—sometimes with a helping hand from volunteers......»»
New AI approach accelerates targeted materials discovery and sets the stage for self-driving experiments
Scientists have developed an AI-based method that helps gather data more efficiently in the search for new materials, allowing researchers to navigate complex design challenges with greater precision and speed......»»
Discovery of a tRNA modification enzyme that also acts on nucleosides
The genetic information on DNA is transcribed into messenger RNA (mRNA) and translated to the amino acid sequence by transfer RNA (tRNA) on the ribosome. Modified nucleosides within RNA are involved in maintaining and regulating the protein synthesis.....»»
De-risking drug discovery with predictive AI
Developing a new drug can take years of research and cost millions of dollars. Still, more than 90% of drug candidates fail in clinical trials, with even more that never make it to the clinical stage. Many drugs fail because they simply aren't safe......»»
Dynamic view of opioid receptor could refine pain relief
Effective pain relief without the debilitating side effects of traditional opioids is closer to becoming a reality thanks to a study by an all-RIKEN team into the structure and dynamics of a drug-bound opioid receptor......»»
Another intermediate-mass black hole discovery at the center of our galaxy
While researching a cluster of stars in the immediate vicinity of the supermassive black hole SgrA* (Sagittarius A*) at the center of our galaxy, an international team of researchers led by PD Dr. Florian Peißker has found signs of another, intermed.....»»
New model explains precise timing of viral cell bursting
New research from Rice University scientists is shedding light on how viruses ensure their survival by precisely timing the release of new viruses. The discovery offers a new theoretical framework for understanding these dynamic biological phenomena......»»
Pompeii skeleton discovery shows another natural disaster may have made Vesuvius eruption even more deadly
Almost 2,000 years ago, Pliny the Younger wrote letters describing the shaking ground as Vesuvius erupted. Now, a collaborative study led by researchers from the Istituto Nazionale di Geofisica e Vulcanologia (INGV) and Pompeii Archaeological Park ha.....»»
Discovery alert: With six new exoplanets, 5,500 discovery milestone passed
On Aug. 24, 2023, more than three decades after the first confirmation of planets beyond our own solar system, scientists announced the discovery of six new exoplanets, stretching that number to 5,502. From zero exoplanet confirmations to more than 5.....»»