Uncovering the role of FOXO1 in vascular development and transcriptional dynamics in endothelial cells
FOXO1, a key transcription factor in cellular processes, governs metabolism, apoptosis, and aging. Despite its significance, the comprehensive regulation of FOXO1 in endothelial cells (EC) remains unexplored......»»
Inequality weakens local governance and public satisfaction, study finds
Local governments in developing countries are crucial for providing public services that promote human development and address challenges like extreme weather, unemployment and crumbling infrastructure. Yet, they often face difficulties in implementi.....»»
Neutrality has played a pivotal, but under-examined, role in international relations, new research shows
Researchers have developed a new way of understanding international relations by analyzing almost 200 years of alliances, hostilities and neutrality between countries......»»
Report analyzes long history of NASA support for commercial space
NASA published a new report on Thursday highlighting 17 agency mechanisms that have directly and indirectly supported the development and growth of the U.S. commercial space sector for the benefit of humanity......»»
Ferns" ancient resilience aids modern ecosystem recovery after disasters
Scientists have suggested an updated framework for the role of ferns in environmental recovery from disaster. Instead of competing with other organisms, ferns may act as facilitators that ease the way for other plants and animals to re-establish them.....»»
Shedding light on snow"s crucial role in Earth"s climate system
EU researchers are braving extreme Arctic conditions to shed light on snow's crucial role in Earth's climate system......»»
Genetically encoded biosensors measure living cells" charge in real time
Biological cells have many vital functions in the organism. For example, they produce proteins, carbohydrates and fats. But they are also responsible for detoxifying harmful molecules and transmitting signals and immune defense steps. A so-called red.....»»
Scientists steer the development of stem cells to regenerate and repair organs
Investigators from Cedars-Sinai and the University of California, San Francisco (UCSF) have identified a new way to deliver instructions that tell stem cells to grow into specific bodily structures, a critical step in eventually regenerating and repa.....»»
Dripstones from Romanian cave offer insights into climate dynamics in Europe
Investigations into precipitation patterns in eastern Central Europe since the end of the last ice age, conducted by an international research team led by Dr. Sophie Warken of Heidelberg University, have shown that dynamic processes in atmospheric ci.....»»
Programming cells: New RNA tool enhances precision in synthetic genetic circuits
Researchers have successfully developed a modular synthetic translational coupling element (SynTCE), significantly enhancing the precision and integration density of genetic circuits in synthetic biology. Their study was recently published in the jou.....»»
New synthesis technique cuts drug development time and cost
A team of chemists from Scripps Research and Rice University has unveiled a novel method to simplify the synthesis of piperidines, a key structural component in many pharmaceuticals. The study, published in Science, combines biocatalytic carbon-hydro.....»»
Study reveals flies more vulnerable than bees to climate change
Despite their reputation as buzzing nuisances, flies serve a critical role as some of the Earth's most prolific pollinators—and new research led by Penn State scientists suggests they are increasingly at risk due to rising global temperatures......»»
Molecular tool demonstrates how bad eggs are identified for destruction by reproductive system
The biological factory that produces reproductive cells has a robust quality control system to identify and eliminate eggs with chromosomal abnormalities. For years, cell biologists have sought to uncover the mechanisms behind this system, relying on.....»»
Researchers highlight role "workhorse protein" plays in keeping nervous system running smoothly
A team of researchers from the University of Massachusetts Amherst is the first to show how proteins called "chaperones" are vital in ensuring that neurons can transmit signals to one another. When this neurotransmission breaks down, devastating dise.....»»
Cellular RNA plays key role in antiviral defense, study finds
Scientists have uncovered a new role for a cell's own RNA in fending off attacks by RNA viruses. Some of the cell's RNA molecules, researchers found, help regulate antiviral signaling. These signals are part of the intricate coordination of immune re.....»»
A new way of thinking about skyrmion motion could lead to more robust electronics
The future storage and processing of data stand to benefit greatly from tiny magnetic whirlpools known as skyrmions, which are robust against noise and may be useful in lower power consumption devices. The development of skyrmion-based technologies h.....»»
Molecular gardening: New enzymes discovered for protein modification pruning
Deubiquitinases (DUBs) are enzymes used by cells to trim protein modifications made from the protein ubiquitin, and thereby regulate proteins. Malfunctioning of DUBs could lead to diseases, including cancer and neurodegenerative disorders......»»
Parental identity, not ethnicity, influences education spending patterns: Study
How much parents spend on their children's education has a big impact on family well-being and a country's overall development. While past studies have suggested that ethnic and racial backgrounds affect this spending, they lacked solid experimental.....»»
Comprehensive analysis reveals hidden genomic evolution of brown algae
Covering over 70% of Earth's surface, the oceans are home to countless life forms that maintain ecological balance and support human well-being. Among these, brown algae (Phaeophyceae) play a crucial role in sustaining coastal habitats, supporting ma.....»»
Uncovering a centaur"s tracks: Scientists examine unique asteroid-comet hybrid
Although our solar system is billions of years old, we've only recently become better acquainted with one of its more dynamic and captivating inhabitants known as (2060) Chiron......»»
Nano drug delivery system eliminates need for complicated carriers
A team of University of Melbourne researchers from the Caruso Nanoengineering Group has created an innovative drug delivery system with outstanding potential to improve drug development......»»