Molecular mechanism of ZDHHC18-mediated palmitoylation of cGAS in innate immunity inhibition
Cyclic GMP-AMP synthase (cGAS), a double-stranded DNA (dsDNA) sensing protein, plays an important role in the strong innate immune response induced by pathogen derived nucleic acids......»»
Pioneering technique reveals new layer of human gene regulation
A technique can determine for the first time how frequently, and exactly where, a molecular event called "backtracking" occurs throughout the genetic material (genome) of any species, a new study shows......»»
Scientists develop new molecular system made from abundant element manganese for photooxidation
Highly reducing or oxidizing photocatalysts are a fundamental challenge in photochemistry. Only a few transition metal complexes with Earth-abundant metal ions have so far advanced to excited state oxidants, including chromium, iron, and cobalt. All.....»»
Examining how molecular orbitals determine stability
Carboxylic acid dianions (fumarate, maleate, and succinate) play a role in coordination chemistry and, to some extent, also in the biochemistry of body cells. An HZB team at BESSY II has now analyzed their electronic structures using RIXS in combinat.....»»
How molecular systems at the origin of life may have evolved: Rise of the nanomachines
By attaching molecules together, scientists at Université de Montréal think they've found how molecular systems at the origin of life evolved to create complex self-regulating functions......»»
Q&A: Research visualizes a precise mechanism for how cells sort their trash
For decades it has been an open question in the ubiquitin research field how proteins are labeled as being defective or unneeded. In a recent study Brenda Schulman, Director at the Max Planck Institute (MPI) of Biochemistry, and Gary Kleiger, Chair o.....»»
Research team identifies new approach to tackling bacterial infections
Researchers at the Icahn School of Medicine at Mount Sinai have identified a new approach to controlling bacterial infections. The findings are described in Nature Structural & Molecular Biology......»»
Researchers discover key to molecular mystery of how plants respond to changing conditions
A team of researchers from the University of Massachusetts Amherst recently published a pioneering study that answers a central question in biology: How do organisms rally a wide range of cellular processes when they encounter a change—either inter.....»»
Decoding the molecular networks of early human development
New international research shines a light on the role of transcription factors during early embryonic development. Transcription factors are proteins that are critical for gene regulation. The study unveiled more than 1,000 protein–protein interact.....»»
Improving accuracy of molecular quantification in high throughput sequencing
A team at NDORMS has developed a new approach to significantly improve the accuracy of RNA sequencing. They have pinpointed the primary source of inaccurate quantification in both short and long-read RNA sequencing, and have introduced the concept of.....»»
Preclinical study uncovers two proteins" crucial role in causing cancer cell growth
Scientists at City of Hope, one of the largest cancer research and treatment organizations in the United States, have discovered a new cellular mechanism that plays an important role in cancer cells' ability to cause disease. The study is published i.....»»
Team discovers mechanism that protects tissue after faulty gene expression
A study at the University of Cologne's CECAD Cluster of Excellence in Aging Research has identified a protein complex that is activated by defects in the spliceosome, the molecular scissors that process genetic information. Future research could lead.....»»
Researchers realize photo-driven nitrogen fixation and ammonia synthesis mediated by lithium hydride
Ammonia is essential for food and future energy supply. In the industry, it is mainly produced by the Haber-Bosch process, which operates at high temperatures and pressures. Due to the high energy consumption and carbon emissions of ammonia industry,.....»»
A type of plastic that can be shape-shifted using tempering
A team of molecular engineers have developed a type of plastic that can be shape-shifted using tempering. In their paper published in the journal Science the team, from the University of Chicago, with a colleagues from the US DEVCOM Army Research Lab.....»»
The secrets of tea plant immunity: Research identifies key phenolamides in battle against anthracnose
Tea anthracnose significantly impacts China's tea production, with no effective control methods currently available. Research has shifted towards phenolamides, secondary metabolites with potential disease resistance properties. Although these compoun.....»»
ALMA spots the shadow of a molecular outflow from a quasar when the universe was less than 1 billion years old
Theoretical predictions have been confirmed with the discovery of an outflow of molecular gas from a quasar when the universe was less than a billion years old......»»
Plant receptors that control immunity and development share a common origin, study finds
Plants are continuously evolving new immune receptors to ever-changing pathogens. Researchers at the RIKEN Center for Sustainable Resource Science (CSRS) have traced the origin and evolutionary trajectory of plant immune receptors. Their discovery wi.....»»
Unveiling and decoding the regulatory mechanisms of secondary cell wall formation
Wood quality is primarily determined by the properties of its secondary cell wall (SCW). Gaining insight into the molecular processes governing SCW development is crucial for the genetic enhancement of wood quality. Although it's established that a m.....»»
Researchers discover molecular mechanism that influences the symmetrical shape of the style
Humans are attracted to symmetry: in our buildings, our gardens, in our potential partners. For plants, the symmetrical shapes of organs are a matter of survival because the form directly impacts the function......»»
To stick or not to stick? Mixed sand columns illuminate design of better materials
Scientists from Tokyo Metropolitan University have been studying the strength and toughness of sand columns made of a mixture of sticky and non-sticky grains. They have uncovered the mechanism behind how the strength changes as grains are mixed in di.....»»
Molecular simulation AI tool reveals unresolved structure of transporter protein
In a groundbreaking study, researchers have unveiled a previously unknown conformational state of a crucial transporter protein, OxlT, which plays a vital role in preventing kidney stone formation. This discovery, achieved through advanced computatio.....»»