Molecular mechanism of ZDHHC18-mediated palmitoylation of cGAS in innate immunity inhibition
Cyclic GMP-AMP synthase (cGAS), a double-stranded DNA (dsDNA) sensing protein, plays an important role in the strong innate immune response induced by pathogen derived nucleic acids......»»
Research identifies mechanism behind drug resistance in malaria parasite
Collaborating researchers have discovered a link between malaria parasites' ability to develop resistance to antimalarial drugs—specifically artemisinin (ART)—through a cellular process called transfer ribonucleic acid (tRNA) modification. tRNA m.....»»
Multi-scale, nanomaterial-based ice inhibition platform enables full-cycle cryogenic protection for mouse oocytes
Safe and high-quality fertility preservation is of growing significance for women in clinical trials. Current primary methods for cryopreserving human oocytes are slow freezing and vitrification, but existing techniques pose risks of biochemical toxi.....»»
Researchers unlock vital insights into metal-nitrogen-carbon catalysts" reaction mechanism
A team of researchers has made significant strides in understanding metal-nitrogen-carbon (M-N-C) catalysts, offering alternatives to expensive platinum-group-metal (PGM) catalysts and a pathway to a greener future......»»
Machine learning and AI aid in predicting molecular selectivity of chemical reactions
There are few problems now that AI and machine learning cannot help overcome. Researchers from the Yokohama National University are using this modern advantage to resolve what conventional methods cannot......»»
Researchers uncover mechanism for short-distance vesicle movements
Researchers at the Hong Kong University of Science and Technology (HKUST) have thrown new light on the mechanism for how vesicles move short distances within specific parts of the cell, an area not understood by scientists......»»
Nature"s 3D printer: Bristle worms form bristles piece by piece
A new interdisciplinary study led by molecular biologist Florian Raible from the Max Perutz Labs at the University of Vienna provides exciting insights into the bristles of the marine annelid worm Platynereis dumerilii. Specialized cells, called chae.....»»
Protein assembly research shows molecular roll of the dice delivers winning combinations
Australian researchers have shed light on the shape-shifting capabilities of protein assemblies, with results that could revolutionize fields from biomanufacturing to vaccine development......»»
Professor sues Meta to allow release of feed-killing tool for Facebook
Section 230 immunity isn’t just for Big Tech companies, lawsuit says. Enlarge (credit: themotioncloud/Getty Images) Ethan Zuckerman wants to release a tool that would allow Facebook users to control what appears in the.....»»
Team develops an epigenome editing toolkit to dissect the mechanisms of gene regulation
Understanding how genes are regulated at the molecular level is a central challenge in modern biology. This complex mechanism is mainly driven by the interaction between proteins called transcription factors, DNA regulatory regions, and epigenetic mo.....»»
A multi-stream network for retrosynthesis prediction
Retrosynthesis aims to predict a set of reactants for producing given molecules, which plays a significant part in the biochemistry field, such as molecular pathway design and drug discovery. Most existing methods only benefit from one kind of inform.....»»
Study reveals new mechanism to explain how continents stabilized
Ancient, expansive tracts of continental crust called cratons have helped keep Earth's continents stable for billions of years, even as landmasses shift, mountains rise and oceans form. A new mechanism proposed by Penn State scientists may explain ho.....»»
Strictly no dancing: Researchers discover "new molecular design rules"
Since the discovery of quantum mechanics more than a hundred years ago, it has been known that electrons in molecules can be coupled to the motion of the atoms that make up the molecules. Often referred to as molecular vibrations, the motion of atoms.....»»
Researchers discover new function of oncoproteins
Researchers at the University of Würzburg have discovered a new function of the oncoprotein MYCN: It not only helps cancer cells to grow stronger, but also makes them more resistant to drugs. The study is published in Molecular Cell......»»
Study pinpoints cellular response to pressure in sea star embryos
An international team of scientists has discovered a new cellular mechanism that explains how cells can adapt to pressure changes during tissue growth by packing themselves into a unique shape......»»
Researchers develop nanotechnology for creating wafer-scale nanoparticle monolayers in seconds
Nanoscale materials present us with astonishing chemical and physical properties that help materialize applications such as single molecular sensing and minimally invasive photothermal therapy—which were once just theories—into reality......»»
Study reveals flaw in long-accepted approximation used in water simulations
Computational scientists at the Department of Energy's Oak Ridge National Laboratory have published a study in the Journal of Chemical Theory and Computation that questions a long-accepted factor in simulating the molecular dynamics of water: the 2-f.....»»
Researchers reveal how molecular roadblocks slow the breakdown of cellulose for biofuels
Cellulose, which helps give plant cell walls their rigid structure, holds promise as a renewable raw material for biofuels—if researchers can accelerate the production process. Compared to the breakdown of other biofuel materials like corn, breakin.....»»
Rich molecular language guides tiny liquid droplet formation in cells
Peering into a biological cell reveals a bustling microscopic world. The workhorses within this realm are specialized structures called organelles that perform vital cellular functions. Curiously, some organelles defy accepted convention: Instead of.....»»
Attosecond core-level spectroscopy reveals real-time molecular dynamics
Chemical reactions are complex mechanisms. Many different dynamic processes are involved, affecting both the electrons and the nucleus of the present atoms. Very often, the strongly coupled electron and nuclear dynamics induce radiation-less relaxati.....»»
First steps toward a whole-body map of molecular responses to exercise
Research definitively confirms that muscle-moving, calorie-burning activity slows the advance of disease, improves cognitive function, boosts the immune system, and reduces rates of mortality from all causes......»»