How a SARS-CoV-2 variant sacrifices tight binding for antibody evasion
Researchers used computer modeling to reveal that one of the three mutations that make variant B.1.351 different from the original SARS-CoV-2 reduces the virus' binding to human cells -- but potentially allows it to escape some antibodies......»»
Enhanced brain delivery of antibodies heightens the potential to treat brain diseases
The blood-brain barrier blocks the entry of antibodies into the brain. This limits the potential use of antibody therapeutics to treat brain diseases, such as brain tumors......»»
Novel approach uses ionic liquids for diverse aptamer applications
Aptamers, nucleic acids capable of selectively binding to viruses, proteins, ions, small molecules, and various other targets, are garnering attention in drug development as potential antibody substitutes for their thermal and chemical stability as w.....»»
Safety of aquatic animals as human protein sources amid SARS-CoV-2 concerns
Aquatic animals have historically constituted a vital and nutritious dietary component for humans, contributing to nearly 20% of animal protein intake for approximately 3.3 billion people. Unlike terrestrial animals, there has been no evidence indica.....»»
New possibilities for the medical use of botulinun toxin A1
PSI researchers have discovered a surprising trick that could expand the possibilities for medical use of botulinun toxin A1, better known under the name Botox, as an active agent. They have developed antibody-like proteins that speed up the enzyme's.....»»
AI generates proteins with exceptional binding strengths
A new study in Nature reports an AI-driven advance in biotechnology with implications for drug development, disease detection, and environmental monitoring. Scientists at the Institute for Protein Design at the University of Washington School of Medi.....»»
The best PS5 controller is finally getting an Xbox variant
An Xbox-compatible version of one of the best third-party controllers for PlayStation 5 comes out early next year......»»
Study presents new pathway for electrochemically controlling ion selectivity
A new study by researchers at the University of Illinois Urbana-Champaign advances fundamental knowledge about the role of solvation in ion binding and presents a new pathway for electrochemically controlling ion selectivity. The study was published.....»»
Ancient ruins were once a site for gruesome animal sacrifices
Burnt offerings, including lots of horses, fill a courtyard at Casas de Turuñuelo. Enlarge / The site at casas del Turuñuelo, with 1 marking the courtyard. (credit: Iborra Eres, et al.) Whether it was to appease a deit.....»»
Could the "central dogma" of biology be misleading bioengineers?
Today, medicines based on antibodies—proteins that fight infection and disease—are prescribed for everything from cancer to COVID-19 to high cholesterol. The antibody drugs are supplied by genetically-engineered cells that function as tiny protei.....»»
Best gifts for Apple fans and iPhone, iPad and Mac owners
Looking for a great gift for the Apple lover in your life? We've picked out great ideas covering all budgets, even if it's tight......»»
New insight on electrochemical reactions—advancing the green transition
Electrochemical reactions are central to green transitions. These reactions use electric current and potential difference to carry out chemical reactions, which enables binding and realizing electric energy from chemical bonds. This chemistry is the.....»»
Novel insights into antibody aggregation expected to open up new avenues for research and therapeutic applications
Antibodies (immunoglobulins) are Y-shaped proteins that recognize and neutralize specific pathogens. Their ability to target specific molecules or cells has made them promising candidates for future drug development. However, their light chains—par.....»»
Study identifies organic alternative for fighting cattle-pestering flies
When cattle are fighting flies in the summer, they gather in tight bunches, leading them to eat less while experiencing more stress and discomfort. Beef producers have limited options for controlling the flies that pester their cattle. Moreover, exis.....»»
Scientists navigate uncharted waters in fish immunology research
Upon infection or immunization, all jawed vertebrate species generate proteins called antibodies that bind and neutralize pathogens. Strong and long-lasting antibody responses in warm-blooded species such as mammals are produced in secondary lymphoid.....»»
Researchers identify dynamic behavior of key SARS-CoV-2 accessory protein
Researchers at Kanazawa University report in the Journal of Physical Chemistry Letters high-speed atomic force microscopy studies that shed light on the possible role of the open reading frame 6 (ORF6) protein in COVID-19 symptoms......»»
Apple Vision Pro followup expected to be a more affordable, cut-down model
A rumored cheaper variant of the Apple Vision Pro could be considerably cheaper than the initial release, with Apple aiming to reduce the cost of components by half.Apple Vision Pro at Apple ParkThe Apple Vision Pro is a very specialized piece of har.....»»
Ineos Grenadier Quartermaster production begins
Ineos Automotive has just begun U.S. deliveries of the Grenadier SUV. The Quartermaster pickup variant will soon follow......»»
Low-pH-dependent RNA binding and oligomerization of SID-1 transmembrane family proteins: Implications for RNA transport
In C. elegans, the protein SID1 plays a crucial role in the systemic RNA interference process by facilitating the transport of exogenous double-stranded RNA into the cytoplasm. Previously, Chen-Yu Zhang's group has already demonstrated that intact pl.....»»
After driving the Hyundai Ioniq 5 N, I finally get EV “engine” sounds
Fake gearshifts and powertrain noises enhance Hyundai’s electric hot hatch—mostly. Enlarge / The regular Hyundai Ioniq 5 is one of our favorite EVs. Now there's a hot hatch variant, and it's great. (credit: Hyundai).....»»
An effective approach for preparing supramolecular polymers at high concentration
Supramolecular polymers (SPs) are molecular assemblies composed of non-covalently bonded small molecules. They show high recyclability originating from their dynamic nature of monomer binding, which is different from covalent polymers with non-biodeg.....»»