Glycerol phosphate serves as a terminator of glycan elongation in cancer malignancy
Dystroglycans on epithelial cell surfaces interact with the extracellular matrix via long sugar chains (called matriglycans), and they are responsible for cell adhesion. Abnormalities in the formation of matriglycans can impair cell adhesion and caus.....»»
Harnessing nanotechnology to understand tumor behavior
A new study conducted by pre-Ph.D. researcher Pablo S. Valera demonstrates the potential of surface-enhanced Raman spectroscopy (SERS) to explore metabolites secreted by cancer cells in cancer research......»»
James McCaffrey, the voice of Max Payne and Alan Wake 2’s Alex Casey, has died
James McCaffrey, the actor known for playing Alex Casey in Alan Wake 2 and the titular character in the Max Payne series, has died after a battle with cancer......»»
Alan Wake and Max Payne voice actor James McCaffrey has died at 65
James McCaffrey, the voice actor for Max Payne, and Alex Casey in Alan Wake and its sequel, has died as a result of cancer at 65......»»
Ultrafast laser technology could offer improved cancer treatment
Ultrafast laser technology continues to surprise. While research in this field may seem rather abstract at first glance, it very often leads to concrete applications. This is particularly true in health care, where the technology can be used to treat.....»»
Nanoparticles amplify potential cancer vaccine power
Johns Hopkins researchers have identified minuscule particles that supercharge therapeutic cancer vaccines, which train the immune system to attack tumors. These new lipid nanoparticles—tiny structures made of fat—not only stimulate a two-pronged.....»»
Advances in nanoscale carrier-based approaches to enhance efficacy of podophyllotoxin
Podophyllotoxin (PPT), an aryltetralin-type lignan isolated from Podophyllum species, exhibits a wide range of biologic and pharmacologic activities, and mainly serves as an antiviral agent or antitumor drug in clinical applications......»»
Scientists identify biosynthetic pathway of chemotherapeutic derived from yew trees
Researchers from the Max Planck Institute of Molecular Plant Physiology have unraveled the biosynthetic pathway of paclitaxel in yew plants, a chemotherapeutic for cancer treatment. This discovery might facilitate the production of this very complex.....»»
A nanoprobe with a barcode: Sensors detect active proteases
Protein-splitting enzymes play an important role in many physiological processes. Such proteases are generally present in an inactive state, only becoming activated under certain conditions. Some are linked to diseases like infections or cancer, maki.....»»
Could the "central dogma" of biology be misleading bioengineers?
Today, medicines based on antibodies—proteins that fight infection and disease—are prescribed for everything from cancer to COVID-19 to high cholesterol. The antibody drugs are supplied by genetically-engineered cells that function as tiny protei.....»»
Reassessing what we can expect from peptides in disease detection
Based on blood tests, it is possible to detect rare genetic diseases, recognize cancer, or determine the inflammation level in the body. Moreover, due to the rapid development of medical diagnostics based on biofluid analysis, many efforts are being.....»»
Novel viral treatment found to be effective against devastating bone cancer in dogs
Researchers from the University of Minnesota partnered with Mayo Clinic to conduct a groundbreaking study that could offer hope for dogs, and potentially humans, diagnosed with osteosarcoma— a devastating bone cancer predominantly affecting childre.....»»
When research study materials don"t speak their participants" language, data can get lost in translation
Imagine your mother has cancer. You just heard about a promising new experimental treatment and want to enroll her in the study. However, your mother immigrated to the U.S. as an adult and speaks limited English. When you reach out to the research te.....»»
Method for containing toxins from mine waste could protect drinking water, prevent cancer
Imagine an abandoned mine site, surrounded by dead trees and dotted with dark, red ponds with no signs of aquatic life. This is the result of mine waste left in the environment that gets weathered by water and air. With exposure to the elements over.....»»
MicroRNA holds clues to why some mammals are cancer-prone
Researchers at the College of Veterinary Medicine (CVM) have identified an important pathway that reveals why some mammals, like humans, dogs, and cats, regularly develop mammary cancer while others, such as horses, pigs, and cows, rarely do......»»
Unlocking the secrets of peptide sequences in cells with AI
Machine learning is now helping researchers analyze the makeup of unfamiliar cells, which could lead to more personalized medicine in the treatment of cancer and other serious diseases......»»
Female toxin-producing newts are surprisingly more poisonous than males
Tetrodotoxin, the neurotoxin that makes a blue-ringed octopus deadly, also protects Taricha newts—but we don't understand how they produce it, or what purposes it serves for them......»»
Recycled phosphorus fertilizer reduces nutrient leaching, maintains yield
A promising new form of ammonium phosphate fertilizer has been field-tested by University of Illinois Urbana-Champaign researchers. The fertilizer, struvite, offers a triple win for sustainability and crop production, as it recycles nutrients from wa.....»»
New platform solves key problems in targeted drug delivery
In recent years, cell and gene therapies have shown significant promise for treating cancer, cystic fibrosis, diabetes, heart disease, HIV/AIDS and other difficult-to-treat diseases. But the lack of effective ways to deliver biological treatments int.....»»
Using the principles of evolution to defeat cancer
November 24 marked 164 years since the publication of Charles Darwin's revolutionary "On the Origin of Species," one of the most influential scientific books ever written. In acknowledgement, 24 November is known as "Evolution Day" or the quirkier ti.....»»
Charity scams get active over the holidays: Expert tips to avoid them
Abandoned animals, kids with cancer, disabled veterans: These and other pitches for charity can move your emotions and have you reaching for your credit card......»»