Glucagon receptor structures uncover new arrestin interaction mechanism
G protein-coupled receptors (GPCRs) are essential for cell signal transduction and constitute the largest drug target protein family. Upon agonist stimulation, these receptors activate multiple downstream transducers, including G proteins and arresti.....»»
Beyond boundaries: Exploring exotic nuclear landscapes and their cosmic implications
Researchers at Peking University in China have successfully observed the elusive 02+ state of 8He, revealing a novel cluster structure with two strongly correlated neutron pairs. This finding provides insights into exotic nuclear structures and thei.....»»
"Operation Triangulation" exposes advanced iMessage attack on security firm
Security experts have disclosed an astonishing four-year campaign of iPhone hacking targeting the Russian security company Kaspersky, which has been labeled "the most sophisticated exploit ever."Researchers uncover a sophisticated iPhone attackOperat.....»»
Battling persistence in tuberculosis bacteria
Researchers at the Indian Institute of Science (IISc), in collaboration with NCBS and InStem, have uncovered an important mechanism that allows the tuberculosis (TB) bacterium to persist in the human host for decades. They found that a single gene in.....»»
Successful test paves the way for magnet production at CERN
The Large Hadron Collider (LHC) needs specific types of magnets to tightly control the beams of particles at its collision points. Called final-focusing quadrupoles, these magnets are installed in the LHC's interaction regions around the experiments......»»
Novel path of intercellular signal sharing discovered in zebrafish experiments
Researchers at the University of Exeter, U.K., have discovered intricate mechanisms of ligand–receptor complex transport via specialized protrusions transporting signaling components between cells, challenging the conventional understanding of cell.....»»
Swift 4-D printing with shape-memory polymers
Shape-memory polymers or shape-shifting materials are smart materials that have gained significant attention within materials science and biomedical engineering in recent years to build smart structures and devices. Digital light processing is a vat.....»»
Researchers study a million galaxies to find out how the universe began
A team of researchers has analyzed more than 1 million galaxies to explore the origin of the present-day cosmic structures, as reported in a recent study published in Physical Review D as an Editors' Suggestion......»»
Laptops’ 2023 quantum leap: 5 computers we’ll still be talking about in 2024
You likely didn't want these PCs this year, but they may impact your future devices. Enlarge (credit: Getty) You'll never uncover The Next Great Thing if you don't deviate from the norm. When looking back at 2023's lapto.....»»
Inside the matrix: Nanoscale patterns revealed within model research organism
Species throughout the animal kingdom feature vital interfaces between the outermost layers of their bodies and the environment. Intricate microscopic structures—featured on the outer skin layers of humans, as one example—are known to assemble in.....»»
Perfluoroalkyl acids found to accelerate DNA degradation, highlighting potential ecological risks
Perfluoroalkyl acids (PFAAs), infamous for their persistence and widespread environmental presence, have long been a concern due to their toxicological impacts. However, the specific ecological consequences of their interaction with environmental DNA.....»»
GPCR structure: Research reveals molecular origins of function for a key drug target
Through an international collaboration, scientists at St. Jude Children's Research Hospital have leveraged data science, pharmacology and structural information to conduct an atomic-level investigation into how each amino acid in the receptor that bi.....»»
Thianthrenium chemistry allows reactivity switch of a nucleophilic amino acid into a versatile intermediate
Chemical diversification of proteins is an important concept in the study of biological processes and the complex structures of the proteins themselves. Researchers from the Max Planck Society have now published their fascinating findings concerning.....»»
Novel AI-based approach for more accurate RNA 3D structure prediction
A research team from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS) has successfully harnessed artificial intelligence (AI) and deep-learning techniques to model atomic-level RNA 3D structures.....»»
Unveiling the role of autophagy in metabolism and growth for tomato fruit development
Autophagy, a eukaryotic mechanism for breaking down cellular components, is a vital process in lytic organelles such as vacuoles in yeast and plants, and lysosomes in animals. Research has predominantly focused on the model plant Arabidopsis, reveali.....»»
Scientists uncover link between ocean weather and global climate, using mechanical rather than statistical analysis
An international team of scientists has found the first direct evidence linking seemingly random weather systems in the ocean with climate on a global scale. Led by Hussein Aluie, an associate professor in the University of Rochester's Department of.....»»
Team discovers relationship between DNA replication timing and how genes fold into 3D structures inside cell nucleus
The intricate process of duplicating genetic information, referred to as DNA replication, lies at the heart of the transmission of life from one cell to another and from one organism to the next. This happens by not just copying the genetic informati.....»»
Viral enhancement of nanomaterial cancer sensor improves early detection
Researchers from SUTD have developed an advanced system of breast cancer cell detection with improved speed and sensitivity, using a viral mechanism to enhance the tool's sensing accuracy......»»
Global inventory of sound production brings us one step closer to understanding aquatic ecosystems
Scientists looking to uncover the mysteries of the underwater world have more valuable information at their fingertips thanks to an international team that has produced an inventory of species confirmed or expected to produce sound underwater......»»
Nanoparticles amplify potential cancer vaccine power
Johns Hopkins researchers have identified minuscule particles that supercharge therapeutic cancer vaccines, which train the immune system to attack tumors. These new lipid nanoparticles—tiny structures made of fat—not only stimulate a two-pronged.....»»
Direct ink writing of high-resolution cellulose structures
Three-dimensional (3D) printing has a significant role in membrane production for water purification and bio-separation, with capacity to create new and cleverly designed structures......»»