Glucagon receptor structures uncover new arrestin interaction mechanism
G protein-coupled receptors (GPCRs) are essential for cell signal transduction and constitute the largest drug target protein family. Upon agonist stimulation, these receptors activate multiple downstream transducers, including G proteins and arresti.....»»
New Antikythera mechanism analysis challenges century-old assumption
Physicists drew on statistical techniques used to analyze gravitational waves. Enlarge / Fragment of the Antikythera mechanism, circa 205 BC, housed in the collection of the National Archaeological Museum, Athens. (credit: Fine A.....»»
Team discovers a new defense mechanism in bacteria
When confronted with an antibiotic, toxic substance, or other source of considerable stress, bacteria are able to activate a defense mechanism using cell-to-cell communication to "warn" unaffected bacteria, which can then anticipate, shield themselve.....»»
Tensor-force effects on nuclear matter in relativistic ab initio theory
Tensor force is a crucial ingredient of the nucleon-nucleon (NN) interaction, and has an important impact on the structural and dynamical properties of the nuclear many-body system. Many efforts have been devoted to studying the influence of the tens.....»»
Microscopic vehicles propelled by swimming green algae could assist biological and environmental research
Researchers have created tiny, vehiclelike structures that can be maneuvered by microscopic algae. The algae are caught in baskets attached to the micromachines, which have been carefully designed to allow them enough room to continue swimming......»»
Pear-derived discovery: A genetic mechanism to fortify crops against drought
A recent study has shed light on a critical genetic mechanism that boosts plants' ability to withstand drought. The research uncovers the role of the transcription factor PbERF3, native to wild pears, which works in concert with the protein PbHsfC1a.....»»
Scientists uncover conserved mechanism of pericentric heterochromatin initiation in vertebrates
A study published in Nature on July 4 by Prof. Zhu Bing from the Institute of Biophysics of the Chinese Academy of Sciences has shed light on the conserved mechanism responsible for the initiation of pericentric heterochromatin in vertebrates......»»
Researchers uncover key mechanisms in chromosome structure development
Researchers at Rice University are making strides in understanding how chromosome structures change throughout the cell's life cycle. Their study on motorized processes that actively influence the organization of chromosomes appears in the Proceeding.....»»
New theory reveals fracture mechanism in soft materials
A new theory has finally deciphered the physical mechanisms of fracture in soft materials. This discovery could soon lead to new, defect-free materials that are more resistant and durable as well as environmentally friendly. The article "Elastic inst.....»»
Graph learning modules enhance drug-target interaction predictions
The identification of drug-target Interactions (DTIs) represents a pivotal link in the process of drug development and design. It plays a crucial role in narrowing the screening range of candidate drug molecules, thereby facilitating the reuse of dru.....»»
Physicists explore how fluctuations shape transport networks
Understanding how transport networks, such as river systems, form and evolve is crucial to optimizing their stability and resilience. It turns out that networks are not all alike. Tree-like structures are adequate for transport, while networks contai.....»»
A review of progress and outlook for photodetectors based on graphene–semiconductor hybrid structures
A recent review summarizes the progress made in graphene-semiconductor hybrid photodetectors over the past decade. It begins by introducing key photodetector performance indicators, providing the basis for an accurate performance evaluation. The revi.....»»
New vestiges of the first life on Earth discovered in Saudi Arabia
Stromatolites are the earliest geological record of life on Earth. These curious biotic structures are made of algae carpets growing toward the light and precipitating carbonates. After their first appearance 3.48 Ga ago, stromatolites dominated the.....»»
apexanalytix Cyber Risk provides instant alerts for supplier data breaches
apexanalytix launched Cyber Risk, a solution that automatically assesses the cybersecurity posture of every supplier, continuously monitors the dark web to uncover risk exposure and responds to threats impacting suppliers in real-time. Business partn.....»»
Researchers uncover protein SRSF1"s uncommon ability to bind and unfold RNA G-quadruplexes
RNA transcription is the genomic process in which a cell produces a duplicate of a gene's DNA sequence. In a study published in Nucleic Acids Research, University of Alabama at Birmingham Department of Chemistry Professor Jun Zhang, Ph.D., and his te.....»»
Simulations demonstrate potential mechanisms of intermediate-mass black hole formation in globular clusters
Joint research led by Michiko Fujii of the University of Tokyo demonstrates a possible formation mechanism of intermediate-mass black holes in globular clusters, star clusters that could contain tens of thousands or even millions of tightly packed st.....»»
AIM algorithm enhances super-resolution microscope images in real time
When trying to measure molecular structures with nanometer precision, every bit of noise shows up in the data: someone walking past the microscope, tiny vibrations in the building and even the traffic outside. A new processing technique removes noise.....»»
Scientists elucidate substrate recognition and proton coupling mechanism of transporter protein VMAT2
Vesicular monoamine transporter 2 (VMAT2) is the only transporter protein in the central nervous system that mediates the storage of monoamine neurotransmitters. It plays a critical role in mediating nerve impulse transmission and neuroprotection......»»
Scientists uncover a multibillion-year epic written into the chemistry of life
The origin of life on Earth has long been a mystery that has eluded scientists. A key question is how much of the history of life on Earth is lost to time. It is quite common for a single species to "phase out" using a biochemical reaction, and if th.....»»
DNA repair mechanism further elucidated in cryo-electron microscopy experiment
Researchers have discovered how the protein XPD detects severe DNA damage and controls its repair......»»
New approach enhances accelerator"s capability to uncover clues from supernovae in lunar dust
Researchers at the China Institute of Atomic Energy (CIAE) have significantly enhanced the method of detecting iron-60 (60Fe), a rare isotope found in lunar samples, using the HI-13 tandem accelerator. This achievement paves the way for detecting 60F.....»»