Cells use concentration gradients as a compass
Biophysicists at Ludwig-Maximilians-Universitaet (LMU) in Munch have developed a new theory, which accounts for the observation that cells can perceive their own shapes, and use this information to direct the distribution of proteins inside the cell......»»
Researchers engineer in vivo delivery system for prime editing, partially restoring vision in mice
Prime editing, a versatile form of gene editing that can correct most known disease-causing genetic mutations, now has a new vehicle to deliver its machinery into cells in living animals......»»
Researchers develop algorithm to determine how cellular "neighborhoods" function in tissues
Researchers from Children's Hospital of Philadelphia (CHOP) have developed a new AI-powered algorithm to help understand how different cells organize themselves into particular tissues and communicate with one another. This new tool was tested on two.....»»
When bad cells go good: Harnessing cellular cannibalism for cancer treatment
Scientists have solved a cellular murder mystery nearly 25 years after the case went cold. Following a trail of evidence from fruit flies to mice to humans revealed that cannibalistic cells likely cause a rare human immunodeficiency. Now the discover.....»»
Fossil evidence of photosynthesis gets a billion years older
Remains of cells from two sites show structures similar to those in present cells. Enlarge / At left, one of the fossils, with stacks of thylakoids highlighted using yellow bars; at right, a higher magnification of the end of the.....»»
VW sees promising test results for potential breakthrough EV battery
Volkswagen AG said its battery startup has seen promising results with solid-state cells for electric vehicles, a win for the German carmaker as it pushes to make EVs more efficient and less expensive......»»
Scientists reveal the inner workings of an essential protein trafficking complex
Like mail carriers who manage to deliver their parcels through snow, rain, heat and gloom, a critical group of mammalian proteins helps cells function properly even under less-than-ideal conditions......»»
Research finds climate-dependent dispersal limitation plays an important role in mountain soil microbiome
Microbial communities are highly diverse, yet the mechanisms underlying microbial community assembly are not well understood. In 1967, Daniel Janzen hypothesized that low climatic variability along elevational gradients results in greater constraints.....»»
How cells accurately assemble complex machinery
Proteins are the workhorses of the cell, carrying out functions to keep everything running smoothly. Some proteins work on their own, but in other cases many proteins assemble together to create a complex machine. These proteins are able to do more w.....»»
Pathogenic bacteria use molecular "shuttle services" to fill their injection apparatus with the right product
Disease-causing bacteria of the genus Salmonella or Yersinia can use tiny injection apparatuses to inject harmful proteins into host cells, much to the discomfort of the infected person. However, it is not only with a view to controlling disease that.....»»
New mapping method illuminates druggable sites on proteins
Identifying new ways to target proteins involved in human diseases is a priority for many researchers around the world. However, discovering how to alter the function of these proteins can be difficult, especially in live cells. Now, scientists from.....»»
Elusive cytonemes guide neural development, provide signaling "express route"
St. Jude Children's Research Hospital scientists found that cytonemes (thin, long, hair-like projections on cells) are important during neural development. Cytonemes connect cells communicating across vast distances but are difficult to capture with.....»»
First step towards synthetic carbon dioxide fixation in living cells
Synthetic biology offers the opportunity to build biochemical pathways for the capture and conversion of carbon dioxide (CO2). Researchers at the Max-Planck-Institute for Terrestrial Microbiology have developed a synthetic biochemical cycle that dire.....»»
A new deep-learning-based analysis toolkit for spatial transcriptomics
Biology and medical researchers use spatial transcriptomics (ST) technologies to detect transcription levels in cells, predict cell types and build a tissue's three-dimensional (3D) structure. However, this analysis can be difficult when there are mu.....»»
Study shows 3D organization of DNA controls cell identity programs
In a complex called chromatin, long strands of DNA in cells' nuclei are tightly wrapped around a scaffolding of proteins, like a rolled-up ball of yarn. A new study by Weill Cornell Medicine investigators reveals that beyond providing a convenient wa.....»»
Breakthrough in nitrile activation is promising pathway for anticancer precursor synthesis
A research team, affiliated with UNIST has unveiled a novel method to produce a selective anticancer precursor substance that targets and eliminates cancer cells. This groundbreaking method, previously existing only in theory, has now been experiment.....»»
Getting to the bottom of how red flour beetles absorb water through their butts
A unique group of cells pumps water into the kidneys to help harvest moisture from the air. Enlarge / Who doesn't thrill to the sight of a microscopic cross-section of a beetle's rectum? You're welcome. (credit: Kenneth Veland Ha.....»»
Shedding light on the origin of the photovoltaic effect in organic–inorganic perovskites
A team led by RIKEN researchers has investigated how special crystals convert light into electricity. Their findings will help inform efforts to improve their efficiency, which could lead to the crystals being used in solar cells. The study is publis.....»»
Novel path of intercellular signal sharing discovered in zebrafish experiments
Researchers at the University of Exeter, U.K., have discovered intricate mechanisms of ligand–receptor complex transport via specialized protrusions transporting signaling components between cells, challenging the conventional understanding of cell.....»»
A chemically defined, xeno-free culture system for culturing and deriving monkey pluripotent stem cells in vitro
Non-human primates (NHPs) have a high degree of similarity to humans compared to other animal models. These similarities manifest at the genetic, physiological, socio-behavioral, and central nervous system levels, making NHPs uniquely suitable for re.....»»
Tesla scrambles to boost Cybertruck battery output
Tesla's Giga Texas factory is churning out 4680 battery cells at a rate only sufficient to power about 24,000 Cybertrucks a year, or about a 10th of the required output, Reuters found......»»