Biosynthesis pathway of a new DNA nucleobase elucidated
DNA is composed of nucleobases represented by the letters A, T, G and C. They form the basis of the genetic code and are present in all living beings. But in a bacteriophage, another base, represented by the letter Z, exists. This exception, the only.....»»
AMP biosynthesis key to longevity and metabolic health in vertebrates, study finds
A recent study led by Dr. Itamar Harel from the Silberman Institute at the Hebrew University of Jerusalem has revealed new insights into the role of AMP biosynthesis in the lifespan and metabolic health of vertebrates......»»
Stuck in slow lane, NHTSA proposes new regulatory path for self-driving vehicles
A top federal safety regulator outlined a new regulatory pathway called AV STEP that could speed the deployment of autonomous vehicles. A notice of proposed rulemaking is expected this fall......»»
Team constructs highly active covalent organic framework from benzimidazole monomer in solvothermal pathway
Hydrogen (H2) is a clean carbon-free fuel with high gravimetric energy density and emerges as an attractive alternative to the unrenewable fossil resource. Photocatalytic water splitting over a semiconductor provides a promising economical and enviro.....»»
New pathway discovered for RNA degradation in iron-rich environments
RNA, an essential biomolecule for life, has been used in environmental applications including monitoring microbial communities, developing pesticides, and quantifying the abundance of pathogenic viruses, such as SARS-CoV-2, in water and wastewater sy.....»»
Dry days trigger leaves to send a surprising growth signal telling roots to keep growing
Scientists at the Sainsbury Laboratory Cambridge University (SLCU) have discovered a new molecular signaling pathway, triggered when leaves are exposed to low humidity, that ensures plant roots keep growing towards water......»»
Akkermansia muciniphila found to regulate cholesterol biosynthesis in the gut
A study led by Duke University has looked into the operating mechanisms of Akkermansia muciniphila, a gut microbe associated with lower rates of metabolic disorders......»»
Scientists quantify regulation factors contributing to flux changes in the central metabolic pathway in yeast
Metabolic reaction flux change is the final result of interacting regulations by intracellular gene expression, transcriptional regulation, protein level, translation modification, and allosteric effect. However, the regulatory mechanism of metabolic.....»»
Study sheds light on biosynthesis and transport of pollen coat precursors in angiosperms
Researchers led by Prof. Qi Xiaoquan from the Institute of Botany of the Chinese Academy of Sciences have systematically demonstrated that pollen coat biosynthesis and transport are complex processes involving compartmentalized biosynthesis, coordina.....»»
Study discovers potential key to a cheaper and more accessible Haemophilus influenzae type b vaccine
The bacterium Haemophilus influenzae type b (Hib) can cause severe diseases such as meningitis and blood poisoning in young children. Researchers from the MHH Institute of Clinical Biochemistry have deciphered the pathway of the bacterial capsule and.....»»
Uncovering the mechanism of photoexcited nucleobases: Is decay fast or suppressed?
The nucleobase molecules carrying the genetic codes are the most important ingredients for life, but they are also very vulnerable. When the ultraviolet component in the sunlight irradiates these molecules, the electrons in the molecules will be exci.....»»
Google Cloud CISO on why the Google Cybersecurity Certificate matters
As part of Google’s commitment to building a strong cybersecurity workforce, the Google Cybersecurity Certificate offers an affordable and accessible pathway to a career in cybersecurity. In this Help Net Security interview, Phil Venables, CISO.....»»
Comprehensive analysis of single plant cells provides new insights into natural product biosynthesis
Plants are impressive in their diversity, but especially in the variety of metabolites they produce. Many plant natural products are highly complex molecules, such as the alkaloids vincristine and vinblastine, which are produced by the Madagascar per.....»»
Unraveling the mysteries of p62-bodies and the cellular recycling pathway
Our body functioning is delicately balanced between the synthesis and breakdown of various cellular components. When these cellular components grow old or get damaged, they are digested by a process called autophagy—literally, "self-eating." This p.....»»
"Sayonara" gene: Scientists uncover a protein in fruit flies that many textbooks say shouldn"t exist
RIKEN geneticists have uncovered a protein in fruit flies that many textbooks say doesn't exist. The protein detects stress in cells and sets them on a pathway to self-destruction when they are overly stressed......»»
Exploring the evolution of cannabinoid biosynthesis in a non-cannabis plant
A South African plant called a wooly umbrella is completely unrelated to the cannabis plant, yet it makes a slew of the active compounds found in cannabis—cannabinoids—including some that may have new medical uses......»»
Fluorescent aromatic nanobelts with unique size-dependent properties
A new type of aromatic nanobelt, methylene-bridged [n]cycloparaphenylene ([n]MCPP), has been synthesized and its properties elucidated by researchers at the Institute of Transformative Bio-molecules (WPI-ITbM) at Nagoya University in Japan, in collab.....»»
Both internal and external stimuli found to control anthocyanin accumulation in fruit
Anthocyanins are important health-promoting pigments that contribute significantly to the nutritional and commercial value of fruits. The anthocyanin biosynthetic pathway is well understood and the key regulatory genes controlling the pathway have be.....»»
Study finds new pathway for clearing misfolded proteins
Misfolded proteins are toxic to cells. They disrupt normal functions and cause some age-related human degenerative diseases, like Alzheimer's, Parkinson's, and Huntington's diseases. Cells work constantly to eliminate misfolded proteins, but these cl.....»»
New insights into an old drug: Scientists discover why aspirin works so well
New research has revealed important information about how aspirin works. Even though this drug has been available commercially since the late 1800s, scientists have not yet fully elucidated its detailed mechanism of action and cellular targets. The n.....»»
Engineering nitrogenases for synthetic nitrogen fixation: From pathway engineering to directed evolution
Fertilizers are one of the main reasons that we are able to grow enough crops to feed the almost 8 billion humans living on Earth. Modern agriculture depends largely on nitrogen-based fertilizers, which significantly increase the yield of crops. Unfo.....»»