Assessing a compound"s activity, not just its structure, could accelerate drug discovery
Assessing a drug compound by its activity, not simply its structure, is a new approach that could speed the search for COVID-19 therapies and reveal more potential therapies for other diseases......»»
DeepMind adds a diffusion engine to latest protein-folding software
Major under-the-hood changes let AlphaFold handle protein-DNA complexes and more. Enlarge / Prediction of the structure of a coronavirus Spike protein from a virus that causes the common cold. (credit: Google DeepMind) M.....»»
Researchers discovery family of natural compounds that selectively kill parasites
An international team led by researchers at the University of Toronto has found a family of natural compounds with potential as new and more effective treatments for parasitic worms. The compounds stall the unique metabolic process that worms use to.....»»
Scientists create black arsenic visible infrared photodetectors
In recent years, the exceptional structure and fascinating electrical and optical properties of two-dimensional (2D) layered crystals have attracted widespread attention. Examples of such crystals include graphene, black phosphorus (BP), and transiti.....»»
A multi-stream network for retrosynthesis prediction
Retrosynthesis aims to predict a set of reactants for producing given molecules, which plays a significant part in the biochemistry field, such as molecular pathway design and drug discovery. Most existing methods only benefit from one kind of inform.....»»
Researchers target spermidine production to combat emerging drug resistance in Salmonella
Food-borne diseases like typhoid, caused by Salmonella Typhimurium, are a severe threat to public health, especially in India. The indiscriminate use of antibiotics has allowed this bacterium to become resistant, posing a major hurdle in treating inf.....»»
Cado Security launches solution for forensic investigations in distroless container environments
Cado Security has introduced a solution for conducting forensic investigations in distroless container environments. With Cado Security’s new offering, security teams can investigate the root cause, scope, and impact of malicious activity detected.....»»
Woodlice hold the new record for smallest dispersers of ingested seeds
Even bugs as small as woodlice can disperse seeds they eat, setting a new record for smallest animal recorded to do so. The Kobe University discovery underscores the crucial yet often overlooked role that small invertebrates play in ecosystems......»»
An adjuvant made in yeast could lower vaccine cost and boost availability
Vaccines save lives, as proven during the recent pandemic, but one component of most vaccines—including the Novavax COVID-19 vaccine—goes unheralded: a molecule or other compound that primes the immune system to mount a more robust defense agains.....»»
Strictly no dancing: Researchers discover "new molecular design rules"
Since the discovery of quantum mechanics more than a hundred years ago, it has been known that electrons in molecules can be coupled to the motion of the atoms that make up the molecules. Often referred to as molecular vibrations, the motion of atoms.....»»
Discovery of ancient Glaswegian shrimp fossil reveals new species
A short but robust little shrimp may have died out over 330 million years ago during the Carboniferous period, but the rare Scottish shellfish has been revitalized as a new species to science and as a Glaswegian......»»
Study underscores new strategies to fight drug-resistant bacteria
Several billion years ago, a genetic arms race began between bacteria and their viral killers. This seemingly eternal struggle continues today, with implications for diseases killing tens of thousands of people around the world each year......»»
Researchers reveal how molecular roadblocks slow the breakdown of cellulose for biofuels
Cellulose, which helps give plant cell walls their rigid structure, holds promise as a renewable raw material for biofuels—if researchers can accelerate the production process. Compared to the breakdown of other biofuel materials like corn, breakin.....»»
Discovery of structural specialization in myriapod ovaries
Elaborate observations reveal the structural specialization within an epithelial layer covering oocytes in the Japanese pill-millipede, Hyleoglomeris japonica, considered absent in Myriapoda. Comparing this result with previous descriptions suggested.....»»
Designing a novel substrate for myogenic differentiation from induced pluripotent stem cells
Since their discovery, researchers have repeatedly demonstrated the potential medical applications of differentiated cells and tissues generated from induced pluripotent stem (iPS) cells. However, a significant hurdle to real-world medical applicatio.....»»
Nanoparticle researchers develop microfluidic platform for better delivery of gene therapy for lung disease
Drug delivery researchers at Oregon State University have developed a device with the potential to improve gene therapy for patients with inherited lung diseases such as cystic fibrosis......»»
Researchers develop bioinspired Bouligand structure for enhanced mechanical properties
Bouligand structures, found in natural materials like fish scales, lobster peritoneum and bones, are known for providing exceptional mechanical properties to biomaterials. While progress has been made in creating bioinspired materials, most research.....»»
Bio-inspired materials" potential for efficient mass transfer boosted by a new twist on a century-old theory
The natural vein structure found within leaves—which has inspired the structural design of porous materials that can maximize mass transfer—could unlock improvements in energy storage, catalysis, and sensing thanks to a new twist on a century-old.....»»
Report: Apple mulling potential partnership with Rivian
Earlier this year, Apple canceled its decade-long Project Titan electric car initiative, but a new report from DigiTimes says that Apple’s electric vehicle ambitions might not be over. According to the story, Apple is “assessing the possibility o.....»»
Ransomware activity is back on track despite law enforcement efforts
Despite significant disruptions for high-profile ransomware gangs LockBit and BlackCat, Q1 2024 became the most active first quarter ever recorded — a 21% increase over Q1 2023, according to Corvus Insurance. In January, Corvus reported that global.....»»
Researchers explore raw materials and firing technology for porcelain from late sixth-century Xing kiln
In the process of firing ceramics, the appearance, structure and properties of ceramics are determined by raw materials and firing technology, so the study of raw materials and firing technology of ancient ceramics has always been a very important ar.....»»