Team develops efficient host-vector system for a model archaeon by solving CRISPR-based host-plasmid conflict
A research group has constructed versatile genetic tools for Saccharolobus islandicus REY15A, one of the very few archaeal models for archaea biology and CRISPR biology research......»»
Microbiome studies help explore treatments for genetic disorders
A collaboration has led to the identification, in a bacterium of the intestine, of new CRISPR-Cas9 molecules that could have a clinical potential to treat genetic diseases such as retinitis pigmentosa, through sub-retinal injections. Anna Cereseto an.....»»
Experts develop way to harness CRISPR technology to deal with antimicrobial resistance
Antimicrobial resistance (AMR) is continuing to increase globally, with rates of AMR in most pathogens increasing and threatening a future in which every day medical procedures may no longer be possible and infections thought long dealt with could ki.....»»
CRISPR is promising to tackle antimicrobial resistance, but bacteria can fight back
In his presentation "How to use CRISPR-Cas to combat AMR" at the ESCMID Global Congress, Assistant Prof. Ibrahim Bitar, Department of Microbiology, Faculty of Medicine and University Hospital in Plzen, Charles University in Prague, Plzen, Czech Repub.....»»
Enhanced CRISPR method enables stable insertion of large genes into the DNA of higher plants
Scientists at the Leibniz Institute of Plant Biochemistry (IPB) have succeeded for the first time in stably and precisely inserting large gene segments into the DNA of higher plants very efficiently. To do this, they optimized the gene-editing method.....»»
New genetic analysis tool tracks risks tied to CRISPR edits
Since its breakthrough development more than a decade ago, CRISPR has revolutionized DNA editing across a broad range of fields. Now scientists are applying the technology's immense potential to human health and disease, targeting new therapies for a.....»»
Searching for data in DNA with CRISPR
The digital age has led to the explosive growth of data of all kinds. Traditional methods for storing data—such as hard drives—are beginning to face challenges due to limited storage capacities. With the growing demand for data storage on the ris.....»»
Using CRISPR gene editing to prevent pigs from getting blue-ear pig disease
A team of bio-scientists affiliated with a host of institutions across the U.S. has developed a gene editing technique to produce newborn pigs immune to porcine reproductive and respiratory syndrome, also known as blue-ear pig disease. The paper is p.....»»
CRISPR/Cas9-mediated targeted mutagenesis of inulin biosynthesis in rubber dandelion
Researchers have leveraged the power of the CRISPR/Cas9 genome editing system to enhance natural rubber production in rubber dandelion (Taraxacum kok-saghyz). The CRISPR system's efficiency and precision offer a promising avenue to address challenges.....»»
A new RNA editing tool could enhance cancer treatment
Cell therapies for cancer can be potentially enhanced using a CRISPR RNA-editing platform, according to a new study published Feb. 21 in Cell......»»
Junk DNA in birds may hold key to safe, efficient gene therapy
The recent approval of a CRISPR-Cas9 therapy for sickle cell disease demonstrates that gene editing tools can do a superb job of knocking out genes to cure hereditary disease. But it's still not possible to insert whole genes into the human genome to.....»»
New toolbox allows engineering of genomes without CRISPR
Belgian researchers from VIB-KULeuven Center for Microbiology and VIB-UGent Center for Plant Systems Biology have developed a new toolbox of 16 different short DNA sequences that allow triggering controlled and specific recombination events in any ge.....»»
New CRISPR tool accelerates and optimizes genome editing
CRISPR/Cas systems have undergone tremendous advancement in the past decade. These precise genome editing tools have applications ranging from transgenic crop development to gene therapy and beyond. And with their recent development of CRISPR-COPIES,.....»»
CRISPR off-switches: A path towards safer genome engineering?
Using CRISPR, an immune system bacteria use to protect themselves from viruses, scientists have harnessed the power to edit genetic information within cells. In fact, the first CRISPR-based therapeutic was recently approved by the FDA to treat sickle.....»»
Meet pAblo·pCasso: A new leap in CRISPR technologies for next-gen genome engineering
A new CRISPR-Cas toolkit, dubbed "pAblo·pCasso," is set to transform the landscape of bacterial genome editing, offering unprecedented precision and flexibility in genetic engineering. The new technology, developed by researchers at The Novo Nordisk.....»»
A CRISPR pioneer looks back as the first gene-editing therapy is approved
In 2007, Luciano Marraffini struck out on what was then a scientifically lonely path: to understand CRISPR, which had been discovered in bacteria only about a decade before......»»
FDA approves first CRISPR therapy—here’s how it works against sickle cell
The landmark treatment turns on another blood protein that prevents sickling. Enlarge / This digitally colorized scanning electron micrograph (SEM) revealed some of the comparative ultrastructural morphology between normal red b.....»»
New enzyme allows CRISPR technologies to accurately target almost all human genes
A team of engineers at Duke University have developed a method to broaden the reach of CRISPR technologies. While the original CRISPR system could only target 12.5% of the human genome, the new method expands access to nearly every gene to potentiall.....»»
Researchers characterize translation inhibition in CRISPR-Cas antiviral defense system
A recent study in Science uses bioinformatic analysis as well as biochemical and structural studies to characterize a novel family of effector proteins, named Cami1. The research shows that when a virus attacks a bacterium, CRISPR-Cas10 signaling mol.....»»
New algorithm finds lots of gene-editing enzymes in environmental DNA
Some are related to DNA-cutting enzymes. Others are a complete mystery. Enlarge / The protein structure of CAS, shown with nucleic acids bound. (credit: Bang Wong, Broad Institute) CRISPR—Clustered Regularly Interspace.....»»