When mad AIOLOS drags IKAROS down: A novel pathogenic mechanism
Researchers have described a novel primary immunodeficiency due to a mutation in AIOLOS. This acts through a novel pathogenic mechanism termed 'heterodimeric interference', whereby when two different proteins bind together in a heterodimer, the mutan.....»»
Studying spaceflight atrophy with machine learning
Even intense exercise by astronauts cannot compensate for muscle atrophy caused by microgravity. Atrophy occurs, in part, by way of an underlying mechanism that regulates calcium uptake. Recent research has shown exposure to spaceflight alters the up.....»»
Researchers uncover human DNA repair by nuclear metamorphosis
Researchers at the University of Toronto have discovered a DNA repair mechanism that advances understanding of how human cells stay healthy, and which could lead to new treatments for cancer and premature aging......»»
New time-resolved ultraviolet photodissociation mass spectrometry strategy for target protein stability analysis
How mutations impact protein stability and structure dynamics is crucial for understanding the molecular mechanism of the disease and the targeted drug design. However, probing the molecular details of mutation-induced subtle structure dynamics is st.....»»
Researchers resolve old mystery of how phages disarm pathogenic bacteria
Bacterial infections pose significant challenges to agriculture and medicine, especially as cases of antibiotic-resistant bacteria continue to rise. In response, scientists at Texas A&M AgriLife Research are elucidating the ways that bacteria-infecti.....»»
Ocean currents threaten to collapse Antarctic ice shelves, study finds
A new study published in Nature Communications has revealed that the interplay between meandering ocean currents and the ocean floor induces upwelling velocity, transporting warm water to shallower depths. This mechanism contributes substantially to.....»»
Researchers develop mechanism of electrical 180° switching of Néel vector in spin-splitting antiferromagnet
A research team led by The Hong Kong University of Science and Technology (HKUST) and Tsinghua University has theoretically proposed a new mechanism of electrical 180° switching of Néel vector and experimentally realized it in antiferromagnetic mat.....»»
Scientists discover new phage resistance mechanism in phage-bacterial arms race
One of the most abundant and deadliest organisms on Earth is a virus called a bacteriophage (phage). These predators have lethal precision against their targets—not humans, but bacteria. Different phages have evolved to target different bacteria an.....»»
Chinese scientists reveal the spinning mechanism of the silkworm
Mulberry silk is a natural protein fiber that is light, soft and fine in nature, known as the "second skin of the human body" and "Queen of fibers." China is the origin of the world's sericulture industry......»»
Researchers discover corn reduces arsenic toxicity in soil
When crops grow in arsenic-contaminated soil, this toxic element accumulates in the food chain. A study involving the University of Basel has now discovered a mechanism used by corn plants to reduce arsenic uptake: the key factor is a special substan.....»»
Researchers observe anomalously bright single-molecule upconversion electroluminescence phenomenon
A research group has developed a new and highly efficient upconversion luminescence mechanism by scanning tunneling microscopy (STM) induced luminescence to observe an extraordinarily bright single-molecule upconversion electroluminescence (UCEL) phe.....»»
Researchers reveal structure and assembly mechanism of unique module in cellulosome
Cellulosomes are multi-enzyme complexes known for their efficient lignocellulose degradation, which is valuable in bioenergy technique development. The diverse composition and intricate assembly of cellulosomes give them exceptional substrate degrada.....»»
Researchers discover new microRNA-regulated pathway to boost iPS cell-derived platelet production
A team of researchers led by Professor Koji Eto (Department of Clinical Application) recently discovered the importance of a microRNA-based regulatory mechanism for enhancing the quality and quantity of platelets generated by iPS cell-derived megakar.....»»
Scientists discover a key quality-control mechanism in DNA replication
When cells in the human body divide, they must first make accurate copies of their DNA. The DNA replication exercise is one of the most important processes in all living organisms and is fraught with risks of mutation, which can lead to cell death or.....»»
Memories of mitosis: Molecular mechanism that detects defects during cell division could aid cancer treatment
Every day, our cells are hard at work multiplying. Cell division is a precise process, but sometimes this process is impaired and diseases like cancer occur. Mitosis is one of the most important phases in the cell cycle. During this phase, a cell's D.....»»
Drama intensifies in Piston Group dispute over minority certification
As a bitter legal fight over the minority status of Piston Group, the country’s largest Black-owned automotive supplier, drags on, a national feud has flared up among the councils in charge of certification......»»
If you"re getting dozens of password reset notifications, you"re being attacked
Apple users are becoming the target of a new wave of phishing attacks called "MFA Bombing" that relies on user impatience, and a bug in Apple's password reset mechanism.An example of the Apple ID password reset notificationPhishing attacks often rely.....»»
Cows in Texas and Kansas test positive for highly pathogenic bird flu
The risk to the public is low, and the milk supply is safe. Enlarge (credit: Getty | Peter Cade) Wild migratory birds likely spread a deadly strain of bird flu to dairy cows in Texas and Kansas, state and federal officia.....»»
Discovery of amino acid unveils how light makes stomata open in plants
Scientists from Nagoya University have discovered a novel regulatory mechanism that controls the opening of stomata in plants, which is crucial for harnessing solar energy through photosynthesis. The team uncovered the role of phosphorylation at the.....»»
Q&A: Clarifying the megathrust earthquake mechanism
There is a 70-80% chance that the Nankai Trough Megathrust Earthquake will occur in the next 30 years. It is predicted to cause more extensive damage than the 2011 Great East Japan Earthquake and fatalities may exceed 320,000......»»
Research challenges "universal mechanism" concept, aiming to understand specific protein interactions
Heat shock proteins (HSPs) are the chaperones of cellular stress response because they help guide the folding and unfolding of other proteins......»»