Screening for macrocyclic peptides
Macrocyclic peptides are promising candidates for pharmaceuticals, but their screening is difficult. Scientists have now developed an easy-to-use, high-throughput screening assay for cyclic peptides with affinity to ubiquitin, a protein that helps to.....»»
Constructing "on-gel" alveolar organoids as a new screening platform
A study led by Professor Shimpei Gotoh (Department of Clinical Application), introduces a new culturing method to generate alveolar organoids suitable for medium- and high-throughput screening and identified several chemicals with synergistic effects.....»»
Mutation solves a century-old mystery in meiosis
A high-throughput genetic screening of meiotic crossover rate mutants in Arabidopsis thaliana has unraveled a century-old mystery in the life sciences......»»
Scientists develop rapid gene-screening platform to boost disease resistance in crops
Scientists at CSIRO, Australia's national science agency, have achieved a breakthrough in molecular plant pathology, marking a technological leap forward for breeding durable disease-resistant crops......»»
Discovery of new plant protein fold may be seed for anti-cancer drugs
University of Michigan researchers are celebrating their discovery of a new plant biochemistry and its unusual ability to form cyclic peptides—molecules that hold promise in pharmaceuticals as they can bind to challenging drug targets......»»
Physicist advancing skin cancer screening and diagnosis using terahertz waves
Ahead of International Day of Women and Girls in Science this Sunday, 11 February, The University of Warwick is shining the spotlight on a physicist who is developing new technology to advance the diagnosis and screening of skin cancers......»»
Innovative screening can detect "cancer fingerprint" in dogs
Cancer is common in dogs, with some breeds being more prone to certain variations of the disease than others. Recent studies have shown that nearly half of dogs over the age of 10 will develop cancer, making early screening a crucial precaution for d.....»»
Scientists develop high-precision droplet printing platform for single cell phenotype screening
With the rapid development of genome synthesis and editing technologies, droplet-based single-cell phenotype screening has become increasingly important. However, precise and high-throughput distribution of target droplets into specific macroscopic m.....»»
Fingerprinting biomolecules with the help of sound
A team of researchers from the Institute for Optoelectronic Systems and Microtechnology at Universidad Politécnica de Madrid (UPM) has designed a biosensor capable of identifying proteins and peptides in quantities as low as a single monolayer. For.....»»
Researchers address formulation, manufacturing challenges in obesity, diabetes drugs
Medications such as Ozempic and Mounjaro are composed of molecules called acylated peptides that are designed to circulate in the body and regulate insulin production. This enables adults with type 2 diabetes to take a weekly injection instead of mon.....»»
Single-cell precision: New screening method greatly accelerates cyanobacterial analysis
Cyanobacteria, as unique photosynthetic prokaryotic organisms, possess the extraordinary ability to directly convert sunlight, seawater, and carbon dioxide into a wide variety of bio-based products......»»
Brazilian researchers discover two novel peptides with biotechnological potential in snake venom
Brazilian snake and spider venoms continue to be a source of new discoveries with biotechnological potential. Two recently published studies show how this is possible even in relatively well-studied species such as the lancehead pit viper Cotiara (Bo.....»»
Oral peptides: A new era in drug development
For decades, a substantial number of proteins, vital for treating various diseases, have remained elusive to oral drug therapy. Traditional small molecules often struggle to bind to proteins with flat surfaces or require specificity for particular pr.....»»
A graphical user interface for analysis and design of protein–peptide interactions
Proteins function through interactions with other proteins or peptides, a complex process that is still not fully understood. Current research focuses on how amino acid residues interact in protein-protein or protein-peptide interactions to establish.....»»
Reassessing what we can expect from peptides in disease detection
Based on blood tests, it is possible to detect rare genetic diseases, recognize cancer, or determine the inflammation level in the body. Moreover, due to the rapid development of medical diagnostics based on biofluid analysis, many efforts are being.....»»
Nature inspires a new wave of biotechnology
Biological molecules called peptides play a key role in many biological activities, including the transport of oxygen and electrons. Peptides consist of short chains of amino acids, the building blocks of proteins. They are also the inspiration for n.....»»
A framework for screening pharmaceuticals and personal care products in landfill leachates
The prevalence of pharmaceuticals and personal care products (PPCPs) in the environment has generated increasing concern due to the potential threats they pose to the ecosystem and human health. Landfill leachate is an important source of PPCPs in wa.....»»
Save $20 on a lifetime plan to this stock screening app
Use Tykr Stock Screener to manage your investments. Get this coupon code for $20 off a lifetime subscription. TL;DR: As of October 7, get $20 off a Tykr Stock Screener Premium Plan Lifetime Subscription.Investing your money may be intimidating,.....»»
Machine-learning-boosted drug discovery with 10-fold time reduction
Boosting virtual screening with machine learning allowed for a 10-fold time reduction in the processing of 1.56 billion drug-like molecules. Researchers from the University of Eastern Finland teamed up with industry and supercomputers to carry out on.....»»
Grisham, Martin join authors suing OpenAI: “There is nothing fair about this” [Updated]
Authors claim ChatGPT wouldn’t exist without their books. Enlarge / George R.R. Martin at an HBO Max screening. (credit: Amy Sussman/GA / Contributor | The Hollywood Reporter) Yesterday, popular authors including John.....»»
Grisham, Martin join authors suing OpenAI: “There is nothing fair about this”
Authors claim ChatGPT wouldn’t exist without their books. Enlarge / George R.R. Martin at an HBO Max screening. (credit: Amy Sussman/GA / Contributor | The Hollywood Reporter) Yesterday, popular authors including John.....»»