Cellular aging: A basic paradox elucidated
Cancer researchers show for the first time that cellular senescence, which occurs when aging cells stop dividing, is caused by irreversible damage to the genome rather than simply by telomere erosion......»»
Shedding light on the mechanism of yeast DNA repair
DNA damage is a cellular phenomenon that introduces structural abnormalities in double-stranded DNA. External factors, such as radiation or chemical agents, as well as internal factors, such as blocked DNA replication, can generate double-strand brea.....»»
Protein mutant stability can be inferred from AI-predicted structures
Researchers at the Center for Algorithmic and Robotized Synthesis within the Institute for Basic Science have taken a significant step forward in understanding the stability of proteins by leveraging the power of AI......»»
Simulation model shows ribosome tunnel"s impact on protein structures
Researchers at University of Tsukuba have developed a new model that simulates the internal environment of a ribosome—the cellular site of protein synthesis. Using computer simulations, they have analyzed the structures of various proteins within t.....»»
Light microscopy study reveals molecular density changes during mitotic chromosome condensation
A team of scientists studying cell division developed a special light microscopy system and used it to analyze the molecular density of cellular environments. Their results provide a novel insight into mitotic chromosome condensation in living human.....»»
X’s Grok will direct users to Vote.gov after bungling basic ballot question
After falsely stating that ballot deadlines passed, Grok sends users to Vote.gov. Enlarge (credit: Getty Images | NurPhoto ) Elon Musk's X platform made a change to its AI assistant, Grok, that may prevent it from giving.....»»
The basic Amazon Kindle has a rare discount at Target
The 2022 Amazon Kindle, which is the latest release of the basic model of the e-book reader, is on sale with a rare $15 discount from Target, but not for long......»»
Low iPad mini stock could hint at impending upgrade with Apple Intelligence
Internal Apple sources suggest iPad mini is "constrained," which hints that the aging device could finally see a refresh in the fall — perhaps with Apple Intelligence support.iPad mini 6Apple revealed the redesigned iPad mini 6 in 2021 and it hasn'.....»»
Scientists use evolution to bioengineer new pathways to sustainable energy and pharmaceuticals
Using evolution as a guiding principle, researchers have successfully engineered bacteria-yeast hybrids to perform photosynthetic carbon assimilation, generate cellular energy and support yeast growth without traditional carbon feedstocks like glucos.....»»
Dissecting caspase-2-mediated cell death: From intrinsic PIDDosome activation to chemical modulation
Caspase-2, an initiator caspase, plays a critical role in programmed cell death in response to certain cellular stresses. Its activation is facilitated by the PIDDosome, a multi-protein complex that assembles under conditions of genotoxic stress. Des.....»»
Discovery of a hidden epigenetic clock in mitochondria reveals a "lifespan limit line"
Building on their work on epigenetics of aging and transposable elements, researchers Dr. Ádám Sturm and Dr. Tibor Vellai from Eötvös Loránd University have made another advance in understanding the molecular mechanisms of aging. Their latest st.....»»
A hybrid arrowhead against immune disorders: Bacterially derived natural product inhibits cellular immune response
The so-called immunoproteasome is essential for the cellular immune response. In autoimmune diseases, however, it is overactive. Until now, it has not been possible to selectively inhibit the immunoproteasome without disrupting other cellular mechani.....»»
Ultra-sensitive photothermal microscopy technique detects single nanoparticles as small as 5 nm
The detection of individual particles and molecules has opened new horizons in analytical chemistry, cellular imaging, nanomaterials, and biomedical diagnostics. Traditional single-molecule detection methods rely heavily on fluorescence techniques, w.....»»
Hubble spots the Tucana Dwarf in the dark
A splatter of stars glows faintly at almost 3 million light-years away in this new image from NASA's Hubble Space Telescope. Known as the Tucana Dwarf for lying in the constellation Tucana, this dwarf galaxy contains a loose bundle of aging stars at.....»»
The secret to sleepy cells" control of inflammatory secretions
Scientists at Sanford Burnham Prebys and the La Jolla Institute for Immunology have revealed a new secret regarding senescence, a cellular state similar to sleep that is more likely to affect aged cells. This drowsy condition is known to provide heal.....»»
Cryo-ET study elucidates protein folding helpers in their natural environment
Cryo-electron tomography (cryo-ET), can be used to visualize and analyze cellular structures in their natural environment. Researchers at the MPI of Biochemistry in Martinsried and the University Medical Center Göttingen have now used cryo-ET to stu.....»»
Unveiling the hottest period in a million years: The MIS 11c paradox
The hottest warm period in the past million years is believed to have occurred about 400,000 years ago. During this time, the Northern Hemisphere had less ice than today, and sea levels were about 10 meters higher. Surprisingly, solar radiation, a ke.....»»
Cellular DNA damage response pathways might be useful against some disease-causing viruses
New research reveals that triggering a cell's DNA damage response could be a promising avenue for developing novel treatments against several rare but devastating viruses for which no antiviral treatments exist, possibly including human papilloma vir.....»»
Pore structure characteristics found to influence carbon mineralization under conservation tillage
Soil aggregates are the basic units of soil structure and serve as a reservoir for soil carbon, playing a crucial role in the carbon cycle of ecosystems. The pore characteristics of soil aggregates influence the mineralization of soil organic carbon......»»
How to turn on the FPS counter on Steam
If you want to see how your game is performing without having to use any third-party software, you can turn on a basic FPS counter on Steam. Here's how......»»
AT&T and Verizon ask FCC to throw a wrench into Starlink’s mobile plan
Carriers allege Starlink/T-Mobile will interfere with existing mobile networks. Enlarge (credit: T-Mobile) AT&T and Verizon are urging telecom regulators to reject a key part of SpaceX's plan to offer cellular service wi.....»»