Breakdown of 3D protein structures: Threaded as an eyelet
It's an old needlework trick, and a protein in our body knows it: Instead of threading yarn into the eye from the end, it can be easier to pass a loop through it. This is how a protein in our body works, unfolding or separating other protein structur.....»»
Key protein regulates immune response to viruses in mammal cells
Researchers have revealed the regulatory mechanism of a specific protein that plays a key role in balancing the immune response triggered by viral infections in mammal cells. These findings could help drive the development of antiviral therapies and.....»»
First evidence of ancient human occupation found in giant lava tube cave in Saudi Arabia
If you look from above, you can see thousands of stone structures dotting the landscape of the Arabian peninsula. On the ground, you can find a bounty of stone tools and ancient fireplaces scattered along the edges of ancient lakes, as well as rock a.....»»
How a calcium-sensing protein multitasks
The calcium-sensing receptor is critical for maintaining healthy calcium levels, but CaSR is also well-known for its side hustles. The receptor is increasingly recognized for its ability to detect other ions and proteins and for its role in breast ca.....»»
A powerful technique for tracking a protein"s fleeting shape changes
Researchers at Weill Cornell Medicine have developed a powerful, new technique to generate "movies" of changing protein structures and speeds of up to 50 frames per second......»»
New class of antimicrobials discovered in soil bacteria
Researchers have discovered toxic protein particles, shaped like umbrellas, that soil bacteria known as Streptomyces secrete to squelch competitors, especially others of their own species......»»
Spintronics: A new path to room temperature swirling spin textures
In some materials, spins form complex magnetic structures within the nanometer and micrometer scale in which the magnetization direction twists and curls along specific directions. Examples of such structures are magnetic bubbles, skyrmions, and magn.....»»
Improved mid-infrared nanoscopy enables 30 times clearer view of the insides of bacteria
A team at the University of Tokyo have constructed an improved mid-infrared microscope, enabling them to see the structures inside living bacteria at the nanometer scale. Mid-infrared microscopy is typically limited by its low resolution, especially.....»»
Illuminating the path to hearing recovery: Structural insights into a receptor protein"s role in auditory function
Researchers have worked to uncover the mysteries surrounding a specific receptor protein associated with hearing. Professor Yunje Cho's research team from the Department of Life Sciences at Pohang University of Science and Technology (POSTECH, Republ.....»»
New time-resolved ultraviolet photodissociation mass spectrometry strategy for target protein stability analysis
How mutations impact protein stability and structure dynamics is crucial for understanding the molecular mechanism of the disease and the targeted drug design. However, probing the molecular details of mutation-induced subtle structure dynamics is st.....»»
Chemists devise easier new method for making a common type of building block for drugs
Ring-shaped chemical structures called saturated heterocycles are found in most FDA-approved drugs but are often difficult to create. Scripps Research chemists have just developed a surprisingly easy method for making many of these sought-after compo.....»»
New study details how starving cells hijack protein transport stations
A new study details how nutrient-starved cells divert protein transport stations to cellular recycling centers to be broken down, highlighting a novel approach cells use to deal with stressful conditions......»»
Researchers develop method to extract useful proteins from beer-brewing leftovers
Researchers from Nanyang Technological University, Singapore (NTU Singapore), have created a method that extracts more than 80% of the available protein in grain leftovers from brewing beer, commonly known as brewers' spent grain......»»
Laptop buying guide: what to look for in 2024
If you're unsure about what you need in a laptop, this laptop buying guide can help. In our breakdown, we'll explain specs, pricing, model types, and more......»»
Researchers discover the secret of how termites build their giant nests
Termites are the architects of the natural world. The nests that they build can reach meters of height, with complex and elaborate structures, galleries that ensure efficient communication and that automatically ventilate the nest interior in a way t.....»»
Laser-patterned thin films that swell into kirigami-like structures offer new opportunities in hydrogel technology
New options for making finely structured soft, flexible and expandable materials called hydrogels have been developed by researchers at Tokyo University of Agriculture and Technology (TUAT)......»»
A promising target for new RNA therapeutics now accessible
Only recently, a new era in medicine began with the first RNA vaccines. These active substances are modified RNAs that trigger immune responses of the human immune system. Another approach in RNA medicine targets the body's own RNA and its protein mo.....»»
New protein imaging method supports the design of innovative new cancer drugs
Scientists have successfully used a new imaging technique to determine the structure and interactions of a protein complex that plays a significant part in the initiation and progression of cancer. They showed that it was possible to use a high-resol.....»»
Scientists reconstruct assembly of the human centriole, image by image, for the first time
Cells contain various specialized structures—such as the nucleus, mitochondria or peroxisomes—known as "organelles." Tracing their genesis and determining their structure is fundamental to understanding cell function and the pathologies linked to.....»»
Scientists report that buffer and pH strongly affect the phase separation of SARS-CoV-2 N protein
In a new paper published in Molecular Biology of the Cell, the Allain lab (IBC) reported that the phase separation of the SARS-CoV-2 N protein strongly depends on the chosen buffer and pH. For example, the protonation of a single histidine side chain.....»»
New method reveals secrets of protein interactions with potential for drug discovery
Scientists from the University of Oulu (Finland) and Texas A&M University (U.S.), have developed a new method to study how proteins interact with small ligand molecules, paving the way, for example, for faster and more efficient drug discovery......»»