"Undruggable" cancer protein becomes druggable, thanks to shrub
A chemist from Purdue University has found a way to synthesize a compound to fight a previously "undruggable" cancer protein with benefits across a myriad of cancer types......»»
The Next Generation of Cancer Drugs Will Be Made in Space
Injectable immunotherapy drugs can be made, in theory, but gravity prevents them from crystallizing correctly. A startup thinks the solution could be right above us......»»
Dual-miRNA triggered DNA nanomachine for breast cancer subtype detection and treatment
Breast cancer is the most common malignancy in women, posing a serious threat to female health. Due to the high inter- and intra-tumoral heterogeneity of breast cancer, clinical treatment and prognosis can vary greatly in patients......»»
Scientists discover how a motor protein helps cells move
Scientists have used the latest advances in microscopy to characterize how a motor protein helps cells crawl, according to a study published in the Journal of Cell Biology......»»
NASA touts space research in anti-cancer fight
Experiments in the weightless environment of space have led to "crazy progress" in the fight against cancer, NASA officials said at a recent event highlighting an important and personal initiative of US President Joe Biden......»»
The next antioxidant superfood? Canadian sea buckthorn berries offer diabetes and obesity potential
New research published in the Journal of the Science of Food and Agriculture illuminates the untapped potential of the shrub sea buckthorn as a rich source of natural antioxidants in North America......»»
High speed protein movies to aid drug design
Researchers from the University of Southampton have developed technology to help scientists observe proteins in motion. Understanding how proteins move will allow novel drugs to be designed......»»
Research challenges "universal mechanism" concept, aiming to understand specific protein interactions
Heat shock proteins (HSPs) are the chaperones of cellular stress response because they help guide the folding and unfolding of other proteins......»»
Scientists elucidate the role of GlyT1 in anti-schizophrenia drugs
Schizophrenia is a highly disabling mental disorder, and numerous studies have shown that the hypofunction of the N-methyl-d-aspartate (NMDA) receptor is one of its pathogenic mechanisms. Glycine transporter 1 (GlyT1), a glycine transporter protein,.....»»
Advances and applications of nanoparticles in cancer therapy
The research team of Prof. Changyang Gong from the Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University has published a new review showing that rapid growth in nanoparticles as delive.....»»
Nanoparticles target multiple COVID variants through the twist in the spike protein
Teardrop-shaped particles designed to inactivate multiple strains of the SARS-CoV-2 virus could one day complement existing treatments for COVID-19, according to a new study led by researchers at the University of Michigan and Jiangnan University in.....»»
Research seeks to develop mRNA lipid nanoparticles for next-generation oral cancer tumor suppressor therapy
A study aiming to develop a lipid nanoparticles (LNP) platform for treating oral squamous cell carcinoma (OSCC) utilizing p53 mRNA was presented at the 102nd General Session of the IADR, which was held in conjunction with the 53rd Annual Meeting of t.....»»
DNA parasite now plays key role in making critical nerve cell protein
An RNA has been adopted to help the production of myelin, a key nerve protein. Enlarge (credit: alex-mit) Human brains (and the brains of other vertebrates) are able to process information faster because of myelin, a fat.....»»
Using adavosertib-encapsulated MOFs for p53-mutated gallbladder cancer treatment via synthetic lethality
Since the revelation of poly(ADP-ribose) polymerase (PARP) inhibitors and their remarkable results in the treatment of BRCA1/2 mutant cancers, synthetic lethality (SL) in antitumor therapy has attracted increasing attention. SL is a phenomenon in whi.....»»
New bioengineered protein design shows promise in fighting COVID-19
In the wake of the COVID-19 pandemic, scientists have been racing to develop effective treatments and preventatives against the virus. A recent scientific breakthrough has emerged from the work of researchers aiming to combat SARS-CoV-2, the virus re.....»»
Research uncovers specific protein interactions needed for cells to break down and remove damaged mitochondria
Autophagy is a process used by cells as a recycling system to transport and break down organelles and other cytosolic components, which become enveloped in a membrane called the autophagosome. When this involves the removal of damaged mitochondria, i.....»»
Deciphering how viruses choose to turn nasty or not to their bacterial host
Researchers from the Shmunis School of Biomedicine and Cancer Research at Tel Aviv University have deciphered a novel complex decision-making process that helps viruses choose to turn nasty or stay friendly to their bacterial host. In a new paper, th.....»»
A simple and robust experimental process for protein engineering
A protein engineering method using simple, cost-effective experiments and machine learning models can predict which proteins will be effective for a given purpose, according to a new study by University of Michigan researchers......»»
"GPS nanoparticle" platform precisely delivers therapeutic payload to cancer cells
A newly developed "GPS nanoparticle" injected intravenously can home in on cancer cells to deliver a genetic punch to the protein implicated in tumor growth and spread, according to researchers from Penn State. They tested their approach in human cel.....»»
New study finds limited correlation between canine lymphoma and proximity to environmental toxins
As awareness of the health risks associated with radon and fracking exposure in connection to cancer continues to rise in human medicine, a recent study explored these ties with multicentric lymphoma, a prevalent canine cancer. Surprisingly, the stud.....»»
New study discovers how altered protein folding drives multicellular evolution
Researchers have discovered a mechanism steering the evolution of multicellular life. They identify how altered protein folding drives multicellular evolution......»»